| HIV Infections
Dovato vs Truvada
Side-by-side clinical, coverage, and cost comparison for hiv infections.Deep comparison between: Dovato vs Truvada with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTruvada has a higher rate of injection site reactions vs Dovato based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Truvada but not Dovato, including UnitedHealthcare
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Category
Dovato
Truvada
At A Glance
Oral
Once daily
INSTI/NRTI combination
Oral
Once daily
NRTI combination (FTC + TDF)
Indications
- HIV Infections
- HIV Infections
Dosing
HIV Infections One tablet (dolutegravir 50 mg/lamivudine 300 mg) orally once daily with or without food; when coadministered with carbamazepine or rifampin, take one additional dolutegravir 50-mg tablet approximately 12 hours after the DOVATO dose.
HIV Infections Adults and pediatric patients weighing >=35 kg: one tablet (200 mg FTC/300 mg TDF) once daily orally with or without food; pediatric patients weighing 17 to <35 kg: weight-based lower-strength tablet (100 mg/150 mg, 133 mg/200 mg, or 167 mg/250 mg) once daily; CrCl 30-49 mL/min: one tablet every 48 hours; CrCl <30 mL/min or hemodialysis: not recommended.
HIV-1 Pre-Exposure Prophylaxis HIV-1 uninfected adults and adolescents weighing >=35 kg: one tablet (200 mg FTC/300 mg TDF) once daily orally with or without food; not recommended if CrCl <60 mL/min.
Contraindications
- Prior hypersensitivity reaction to dolutegravir or lamivudine
- Concurrent use of dofetilide due to risk of increased dofetilide plasma concentrations and serious or life-threatening events
- Unknown or positive HIV-1 status when used for HIV-1 PrEP
Adverse Reactions
Most common (>=2%) Headache, nausea, diarrhea, insomnia, fatigue, anxiety, dizziness
Serious Hypersensitivity reactions, hepatotoxicity, lactic acidosis and severe hepatomegaly with steatosis, immune reconstitution syndrome
Postmarketing Body fat redistribution, hyperglycemia, weakness, severe anemia, lactic acidosis and hepatic steatosis, pancreatitis, posttreatment exacerbations of HBV, acute liver failure, anaphylaxis, urticaria, weight gain, arthralgia, CPK elevation, muscle weakness, myalgia, rhabdomyolysis, paresthesia, peripheral neuropathy, alopecia
Most common (>=10%) Diarrhea, nausea, fatigue, headache, dizziness, depression, insomnia, abnormal dreams, rash
Serious Severe acute exacerbations of hepatitis B, new onset or worsening renal impairment, immune reconstitution syndrome, bone loss and mineralization defects, lactic acidosis/severe hepatomegaly with steatosis
Postmarketing Allergic reaction including angioedema, lactic acidosis, hypokalemia, hypophosphatemia, dyspnea, pancreatitis, hepatic steatosis, hepatitis, rash, rhabdomyolysis, osteomalacia, muscular weakness, myopathy, acute renal failure, Fanconi syndrome, proximal renal tubulopathy, interstitial nephritis, nephrogenic diabetes insipidus, proteinuria, asthenia
Pharmacology
DOVATO is a fixed-dose combination of dolutegravir, an HIV-1 integrase strand transfer inhibitor (INSTI) that blocks retroviral DNA integration by binding to the integrase active site, and lamivudine, a nucleoside analogue reverse transcriptase inhibitor (NRTI) that inhibits reverse transcriptase via DNA chain termination after incorporation of the nucleotide analogue.
FTC and TDF are both nucleoside analog reverse transcriptase inhibitors (NRTIs); each is converted intracellularly to an active triphosphate form that inhibits HIV-1 reverse transcriptase by competing with natural dNTP substrates and causing chain termination. No antagonism between FTC and TDF has been observed in cell culture combination studies.
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Most Common Insurance
Anthem BCBS
Dovato
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
Truvada
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Dovato
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (7/8)
Truvada
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (8/8)
Humana
Dovato
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Truvada
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableGood Days: HIV, AIDS Treatment & Prevention
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$0
Gilead Advancing Access Patient Assistance Program/Medication Assistance Program (PAP/MAP)Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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DovatoView full Dovato profile
TruvadaView full Truvada profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.