| Human immunodeficiency virus I infection
Descovy for PrEP vs Isentress
Side-by-side clinical, coverage, and cost comparison for human immunodeficiency virus i infection.Deep comparison between: Descovy vs Isentress with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsIsentress has a higher rate of injection site reactions vs Descovy based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Isentress but not Descovy, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Descovy
Isentress
At A Glance
Oral
Daily
NRTI combination
Oral
Once or twice daily
HIV-1 integrase strand transfer inhibitor
Indications
- Human immunodeficiency virus I infection
- Human immunodeficiency virus I infection
Dosing
Human immunodeficiency virus I infection Adults and pediatric patients >=35 kg: one 200 mg/25 mg tablet once daily with or without food; pediatric patients 25 to <35 kg: one 200 mg/25 mg tablet once daily; 14 to <25 kg: one 120 mg/15 mg tablet once daily (with other antiretrovirals including DRV+COBI but not other PI/ritonavir or PI/cobicistat combinations); not recommended with eGFR 15-30 mL/min or <15 mL/min without chronic hemodialysis.
HIV-1 PrEP One 200 mg/25 mg tablet once daily orally with or without food in adults and adolescents >=35 kg with eGFR >=30 mL/min, or adults with eGFR <15 mL/min on chronic hemodialysis (dose after hemodialysis); not recommended with eGFR 15-30 mL/min or <15 mL/min without hemodialysis.
Human immunodeficiency virus I infection (adults, treatment-naive or virologically suppressed on ISENTRESS 400 mg twice daily) 1200 mg (2 x 600 mg) once daily or 400 mg twice daily orally, with or without food.
Human immunodeficiency virus I infection (adults, treatment-experienced) 400 mg twice daily orally, with or without food.
Human immunodeficiency virus I infection (adults, coadministration with rifampin) 800 mg (2 x 400 mg) twice daily orally.
Human immunodeficiency virus I infection (pediatrics >= 40 kg, treatment-naive or virologically suppressed on ISENTRESS 400 mg twice daily) 1200 mg (2 x 600 mg) once daily, 400 mg twice daily, or 300 mg (3 x 100 mg) chewable tablets twice daily orally.
Human immunodeficiency virus I infection (pediatrics >= 25 kg) 400 mg film-coated tablet twice daily orally; weight-based chewable tablet dosing twice daily if unable to swallow tablet.
Human immunodeficiency virus I infection (pediatrics 3 kg to < 25 kg, >= 4 weeks of age) Weight-based dosing using chewable tablet or oral suspension twice daily orally (approximately 6 mg/kg/dose).
Human immunodeficiency virus I infection (neonates birth to 4 weeks, >= 2 kg) Weight-based oral suspension: once daily dosing (~1.5 mg/kg/dose) from birth to 1 week; twice daily dosing (~3 mg/kg/dose) from 1 to 4 weeks of age.
Contraindications
- Unknown or positive HIV-1 status when used for HIV-1 PrEP
—
Adverse Reactions
Most common (>=10%) Nausea (in antiretroviral treatment-naive adults with HIV-1 receiving FTC+TAF with EVG+COBI)
Serious Severe acute exacerbations of hepatitis B, immune reconstitution syndrome, new onset or worsening renal impairment, lactic acidosis/severe hepatomegaly with steatosis
Postmarketing Angioedema, urticaria, rash, acute renal failure, acute tubular necrosis, proximal renal tubulopathy, Fanconi syndrome
Most common (>=2%) Headache, insomnia, nausea, dizziness, fatigue.
Serious Myopathy, rhabdomyolysis, hepatitis, hepatic failure, depression including suicidal ideation and behaviors, nephrolithiasis, renal failure, hypersensitivity.
Postmarketing Thrombocytopenia, diarrhea, hepatic failure, rhabdomyolysis, cerebellar ataxia, anxiety, paranoia.
Pharmacology
Dual HIV NRTI combination; emtricitabine (FTC) and tenofovir alafenamide (TAF) each inhibit HIV-1 reverse transcriptase via nucleotide analog chain termination after intracellular phosphorylation, with TAF serving as a prodrug converted intracellularly to tenofovir and then to the active metabolite tenofovir diphosphate.
Raltegravir inhibits the catalytic activity of HIV-1 integrase, an HIV-1-encoded enzyme required for viral replication, preventing integration of unintegrated linear HIV-1 DNA into the host cell genome; it is eliminated primarily via UGT1A1-mediated glucuronidation and does not inhibit or induce cytochrome P450 enzymes.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Descovy
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (1/12) · Qty limit (11/12)
Isentress
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Descovy
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (6/8)
Isentress
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Descovy
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Isentress
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$0
Gilead Advancing Access Patient Assistance Program/Medication Assistance Program (PAP/MAP)Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableGood Days: HIV, AIDS Treatment & Prevention
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
DescovyView full Descovy profile
IsentressView full Isentress profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.