| Hypercholesterolemia, Familial
Crestor vs Atorvaliq
Side-by-side clinical, coverage, and cost comparison for hypercholesterolemia, familial.Deep comparison between: Crestor vs Atorvaliq with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAtorvaliq has a higher rate of injection site reactions vs Crestor based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Atorvaliq but not Crestor, including UnitedHealthcare
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Category
Crestor
Atorvaliq
At A Glance
Oral
Once daily
HMG-CoA reductase inhibitor
Oral
Daily
HMG-CoA reductase inhibitor
Indications
- Cardiovascular Diseases
- Hyperlipidemia
- Atherosclerosis
- Hypercholesterolemia, Familial
- Hypertriglyceridemia
- Coronary heart disease
- Diabetes Mellitus, Non-Insulin-Dependent
- Heart failure
- Hyperlipidemia
- Hypercholesterolemia, Familial
- Hypertriglyceridemia
Dosing
Cardiovascular Diseases, Hyperlipidemia, Atherosclerosis, Hypertriglyceridemia 5-40 mg orally once daily in adults.
Hypercholesterolemia, Familial HeFH: 5-10 mg once daily (ages 8 to <10 years) or 5-20 mg once daily (ages 10+); HoFH: 20 mg once daily (ages 7+); adults: 5-40 mg once daily.
Coronary heart disease, Diabetes Mellitus Non-Insulin-Dependent, Heart failure, Hyperlipidemia, Hypertriglyceridemia 10 or 20 mg once daily orally on an empty stomach; dosage range 10-80 mg once daily; patients requiring LDL-C reduction >45% may start at 40 mg once daily.
Hypercholesterolemia, Familial (HeFH, pediatric >= 10 years) 10 mg once daily orally on an empty stomach; dosage range 10-20 mg once daily.
Hypercholesterolemia, Familial (HoFH, pediatric >= 10 years) 10-20 mg once daily orally on an empty stomach; dosage range 10-80 mg once daily.
Contraindications
- Acute liver failure or decompensated cirrhosis
- Hypersensitivity to rosuvastatin or any excipient in CRESTOR
- Acute liver failure or decompensated cirrhosis
- Hypersensitivity to atorvastatin or any excipients in ATORVALIQ
Adverse Reactions
Most common (>=2%) headache, nausea, myalgia, asthenia, constipation, arthralgia, dizziness, increased CPK, abdominal pain, diabetes mellitus
Serious myopathy, rhabdomyolysis, immune-mediated necrotizing myopathy, hepatic dysfunction, proteinuria, hematuria, increases in HbA1c and fasting serum glucose
Postmarketing thrombocytopenia, hepatitis, jaundice, hepatic failure, peripheral neuropathy, cognitive impairment, myasthenia gravis, depression, sleep disorders, gynecomastia, interstitial lung disease, DRESS, lichenoid drug eruption
Most common (>=2%) Nasopharyngitis, arthralgia, diarrhea, pain in extremity, urinary tract infection, dyspepsia, nausea, musculoskeletal pain, muscle spasms, myalgia, insomnia, pharyngolaryngeal pain
Serious Myopathy, rhabdomyolysis, immune-mediated necrotizing myopathy, hepatic dysfunction, increases in HbA1c and fasting serum glucose
Postmarketing Pancreatitis, fatigue, fatal and non-fatal hepatic failure, anaphylaxis, tendon rupture, rhabdomyolysis, myositis, dizziness, peripheral neuropathy, cognitive impairment, depression, interstitial lung disease, angioneurotic edema, bullous rashes
Pharmacology
CRESTOR (rosuvastatin) is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme converting HMG-CoA to mevalonate (a cholesterol precursor); inhibition accelerates hepatic LDL-receptor expression, reducing plasma LDL-C, total cholesterol, and VLDL levels.
Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts HMG-CoA to mevalonate, a cholesterol precursor; it lowers plasma cholesterol and LDL levels by inhibiting hepatic cholesterol synthesis and increasing hepatic LDL receptor expression.
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Most Common Insurance
Anthem BCBS
Crestor
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (0/12)
No coverage data available for Atorvaliq.
UnitedHealthcare
Crestor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
No coverage data available for Atorvaliq.
Humana
Crestor
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
No coverage data available for Atorvaliq.
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Crestor.
No savings programs available for Atorvaliq.
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CrestorView full Crestor profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.