| Hypercholesterolemia
Leqvio vs Nexlizet
Side-by-side clinical, coverage, and cost comparison for hypercholesterolemia.Deep comparison between: Leqvio vs Nexlizet with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNexlizet has a higher rate of injection site reactions vs Leqvio based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nexlizet but not Leqvio, including UnitedHealthcare
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Category
Leqvio
Nexlizet
At A Glance
SC injection
Every 6 months (after initial doses)
PCSK9 siRNA
Oral
Daily
ACL inhibitor / cholesterol absorption inhibitor
Indications
- Hypercholesterolemia
- Familial hypercholesterolemia - heterozygous
- Homozygous Familial Hypercholesterolemia
- Hypercholesterolemia
- Atherosclerosis
Dosing
Hypercholesterolemia, Familial hypercholesterolemia - heterozygous, Homozygous Familial Hypercholesterolemia 284 mg SC injection initially, again at 3 months, then every 6 months; administered by a healthcare professional into abdomen, upper arm, or thigh.
Hypercholesterolemia, Atherosclerosis One tablet (180 mg bempedoic acid and 10 mg ezetimibe) orally once daily, with or without food.
Coadministration with bile acid sequestrants Administer at least 2 hours before or at least 4 hours after bile acid sequestrants.
Contraindications
- Prior serious hypersensitivity reaction to inclisiran or any excipient in LEQVIO (including anaphylaxis and angioedema)
- Prior hypersensitivity to ezetimibe or bempedoic acid or any of the excipients in NEXLIZET
Adverse Reactions
Most common (>=3%) Injection site reaction, arthralgia, bronchitis
Postmarketing Anaphylaxis, angioedema, rash, pruritus, urticaria
Most common (>=2%) Upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, elevated liver enzymes, diarrhea, arthralgia, sinusitis, fatigue, influenza
Serious Hyperuricemia, tendon rupture
Postmarketing Thrombocytopenia, abdominal pain, pancreatitis, nausea, hepatitis, cholelithiasis, cholecystitis, anaphylaxis, angioedema, myopathy/rhabdomyolysis, dizziness, paresthesia, depression, headache, erythema multiforme
Pharmacology
PCSK9 siRNA; inclisiran is a double-stranded siRNA conjugated with GalNAc that directs catalytic breakdown of PCSK9 mRNA in hepatocytes, increasing LDL-C receptor recycling and expression on the hepatocyte cell surface to reduce circulating LDL-C.
NEXLIZET combines bempedoic acid, an ACL inhibitor that lowers LDL-C by blocking hepatic cholesterol synthesis upstream of HMG-CoA reductase via inhibition of ATP-citrate lyase, with ezetimibe, which reduces LDL-C by inhibiting intestinal cholesterol absorption via the NPC1L1 sterol transporter, together acting through complementary mechanisms to decrease circulating LDL-C.
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Most Common Insurance
Anthem BCBS
Leqvio
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Nexlizet
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (11/12) · Qty limit (11/12)
UnitedHealthcare
Leqvio
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Nexlizet
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (6/8)
Humana
Leqvio
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (2/3)
Nexlizet
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableHealthWell: Hypercholesterolemia - Medicare Access
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Nexlizet.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.