| Hypercholesterolemia
Nexlizet vs Leqvio
Side-by-side clinical, coverage, and cost comparison for hypercholesterolemia.Deep comparison between: Nexlizet vs Leqvio with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLeqvio has a higher rate of injection site reactions vs Nexlizet based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Leqvio but not Nexlizet, including UnitedHealthcare
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Category
Nexlizet
Leqvio
At A Glance
Oral
Daily
ACL inhibitor / cholesterol absorption inhibitor
SC injection
Every 6 months (after initial doses)
PCSK9 siRNA
Indications
- Hypercholesterolemia
- Atherosclerosis
- Hypercholesterolemia
- Familial hypercholesterolemia - heterozygous
- Homozygous Familial Hypercholesterolemia
Dosing
Hypercholesterolemia, Atherosclerosis One tablet (180 mg bempedoic acid and 10 mg ezetimibe) orally once daily, with or without food.
Coadministration with bile acid sequestrants Administer at least 2 hours before or at least 4 hours after bile acid sequestrants.
Hypercholesterolemia, Familial hypercholesterolemia - heterozygous, Homozygous Familial Hypercholesterolemia 284 mg SC injection initially, again at 3 months, then every 6 months; administered by a healthcare professional into abdomen, upper arm, or thigh.
Contraindications
- Prior hypersensitivity to ezetimibe or bempedoic acid or any of the excipients in NEXLIZET
- Prior serious hypersensitivity reaction to inclisiran or any excipient in LEQVIO (including anaphylaxis and angioedema)
Adverse Reactions
Most common (>=2%) Upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, elevated liver enzymes, diarrhea, arthralgia, sinusitis, fatigue, influenza
Serious Hyperuricemia, tendon rupture
Postmarketing Thrombocytopenia, abdominal pain, pancreatitis, nausea, hepatitis, cholelithiasis, cholecystitis, anaphylaxis, angioedema, myopathy/rhabdomyolysis, dizziness, paresthesia, depression, headache, erythema multiforme
Most common (>=3%) Injection site reaction, arthralgia, bronchitis
Postmarketing Anaphylaxis, angioedema, rash, pruritus, urticaria
Pharmacology
NEXLIZET combines bempedoic acid, an ACL inhibitor that lowers LDL-C by blocking hepatic cholesterol synthesis upstream of HMG-CoA reductase via inhibition of ATP-citrate lyase, with ezetimibe, which reduces LDL-C by inhibiting intestinal cholesterol absorption via the NPC1L1 sterol transporter, together acting through complementary mechanisms to decrease circulating LDL-C.
PCSK9 siRNA; inclisiran is a double-stranded siRNA conjugated with GalNAc that directs catalytic breakdown of PCSK9 mRNA in hepatocytes, increasing LDL-C receptor recycling and expression on the hepatocyte cell surface to reduce circulating LDL-C.
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Most Common Insurance
Anthem BCBS
Nexlizet
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (11/12) · Qty limit (11/12)
Leqvio
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Nexlizet
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (6/8)
Leqvio
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Nexlizet
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Leqvio
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Nexlizet.
Cost estimate not availableHealthWell: Hypercholesterolemia - Medicare Access
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.