| Hypertensive disease
Benicar HCT vs Cleviprex
Side-by-side clinical, coverage, and cost comparison for hypertensive disease.Deep comparison between: Benicar Hct vs Cleviprex with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCleviprex has a higher rate of injection site reactions vs Benicar Hct based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Cleviprex but not Benicar Hct, including UnitedHealthcare
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Category
Benicar Hct
Cleviprex
At A Glance
Oral
Daily
ARB / thiazide diuretic
IV infusion
Continuous infusion
Dihydropyridine CCB
Indications
- Hypertensive disease
- Hypertensive disease
Dosing
Hypertensive disease Starting dose 40/12.5 mg or 20/12.5 mg once daily depending on prior monotherapy; titrate up to 40/25 mg if needed.
Hypertensive disease Initiate IV infusion at 1-2 mg/hour; double dose at 90-second intervals initially, then increase by less than doubling every 5-10 minutes as goal blood pressure is approached; maintenance 4-6 mg/hour; maximum 16 mg/hour (up to 32 mg/hour for severe hypertension); lipid load limit 1000 mL or an average of 21 mg/hour per 24 hours.
Contraindications
- Hypersensitivity to any component of BENICAR HCT
- Anuria
- Coadministration with aliskiren in patients with diabetes
- Allergy to soybeans, soy products, eggs, or egg products
- Defective lipid metabolism such as pathologic hyperlipemia, lipoid nephrosis, or acute pancreatitis accompanied by hyperlipidemia
- Severe aortic stenosis
Adverse Reactions
Most common (>2%) Dizziness, upper respiratory infection, hyperuricemia, nausea
Serious Hypotension, impaired renal function, hypersensitivity reactions, electrolyte and metabolic imbalances, acute myopia and secondary angle-closure glaucoma, systemic lupus erythematosus, sprue-like enteropathy
Postmarketing Asthenia, vomiting, hyperkalemia, rhabdomyolysis, alopecia, pruritus
Most common Headache, nausea, vomiting, acute renal failure, atrial fibrillation
Serious Myocardial infarction, cardiac arrest, syncope, dyspnea
Postmarketing Increased blood triglycerides, ileus, hypersensitivity, hypotension, nausea, decreased oxygen saturation, reflex tachycardia
Pharmacology
Olmesartan medoxomil selectively blocks angiotensin II binding to the AT1 receptor in vascular smooth muscle, inhibiting vasoconstriction independent of angiotensin II synthesis pathways; hydrochlorothiazide is a thiazide diuretic that directly increases renal excretion of sodium and chloride, reducing plasma volume to lower blood pressure.
Clevidipine is a dihydropyridine L-type calcium channel blocker that lowers blood pressure by inhibiting calcium influx in arterial smooth muscle, reducing systemic vascular resistance without affecting venous preload or cardiac filling pressure.
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Most Common Insurance
Anthem BCBS
Benicar Hct
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (10/12)
Cleviprex
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Benicar Hct
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Cleviprex
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Benicar Hct
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Cleviprex
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Benicar Hct.
No savings programs available for Cleviprex.
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Benicar HctView full Benicar Hct profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.