| Hypertensive disease
Benicar HCT vs Tribenzor
Side-by-side clinical, coverage, and cost comparison for hypertensive disease.Deep comparison between: Benicar Hct vs Tribenzor with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTribenzor has a higher rate of injection site reactions vs Benicar Hct based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tribenzor but not Benicar Hct, including UnitedHealthcare
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Category
Benicar Hct
Tribenzor
At A Glance
Oral
Daily
ARB / thiazide diuretic
Oral
Daily
ARB / CCB / thiazide diuretic
Indications
- Hypertensive disease
- Hypertensive disease
Dosing
Hypertensive disease Starting dose 40/12.5 mg or 20/12.5 mg once daily depending on prior monotherapy; titrate up to 40/25 mg if needed.
Hypertensive disease Once daily; dosage may be increased in 2-week intervals as needed; maximum recommended dose is 40/10/25 mg; dose selection should be individualized based on previous therapy.
Contraindications
- Hypersensitivity to any component of BENICAR HCT
- Anuria
- Coadministration with aliskiren in patients with diabetes
- Anuria
- Hypersensitivity to any component of Tribenzor or to other sulfonamide-derived drugs
- Co-administration of aliskiren in patients with diabetes
Adverse Reactions
Most common (>2%) Dizziness, upper respiratory infection, hyperuricemia, nausea
Serious Hypotension, impaired renal function, hypersensitivity reactions, electrolyte and metabolic imbalances, acute myopia and secondary angle-closure glaucoma, systemic lupus erythematosus, sprue-like enteropathy
Postmarketing Asthenia, vomiting, hyperkalemia, rhabdomyolysis, alopecia, pruritus
Most common (>=2%) Dizziness, peripheral edema, headache, fatigue, nasopharyngitis, muscle spasms, nausea, upper respiratory tract infection, diarrhea, urinary tract infection, joint swelling
Postmarketing Angioedema, anaphylactic reactions, rhabdomyolysis, acute renal failure, sprue-like enteropathy, hyperkalemia, alopecia, pruritus, urticaria, gynecomastia, jaundice, hepatic enzyme elevations, extrapyramidal disorder, non-melanoma skin cancer (hydrochlorothiazide)
Pharmacology
Olmesartan medoxomil selectively blocks angiotensin II binding to the AT1 receptor in vascular smooth muscle, inhibiting vasoconstriction independent of angiotensin II synthesis pathways; hydrochlorothiazide is a thiazide diuretic that directly increases renal excretion of sodium and chloride, reducing plasma volume to lower blood pressure.
Triple-combination antihypertensive; olmesartan medoxomil selectively blocks angiotensin II AT1 receptors in vascular smooth muscle, amlodipine inhibits transmembrane calcium ion influx into vascular and cardiac smooth muscle, and hydrochlorothiazide promotes renal excretion of sodium and chloride to reduce intravascular volume.
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Most Common Insurance
Anthem BCBS
Benicar Hct
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (10/12)
Tribenzor
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Benicar Hct
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Tribenzor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Benicar Hct
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Tribenzor
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Benicar Hct.
No savings programs available for Tribenzor.
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Benicar HctView full Benicar Hct profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.