| Hypertriglyceridemia
Crestor vs Vascepa
Side-by-side clinical, coverage, and cost comparison for hypertriglyceridemia.Deep comparison between: Crestor vs Vascepa with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVascepa has a higher rate of injection site reactions vs Crestor based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vascepa but not Crestor, including UnitedHealthcare
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Category
Crestor
Vascepa
At A Glance
Oral
Once daily
HMG-CoA reductase inhibitor
Oral
Twice daily
Omega-3 fatty acid
Indications
- Cardiovascular Diseases
- Hyperlipidemia
- Atherosclerosis
- Hypercholesterolemia, Familial
- Hypertriglyceridemia
- Myocardial Infarction
- Cerebrovascular accident
- Angina, Unstable
- Hypertriglyceridemia
Dosing
Cardiovascular Diseases, Hyperlipidemia, Atherosclerosis, Hypertriglyceridemia 5-40 mg orally once daily in adults.
Hypercholesterolemia, Familial HeFH: 5-10 mg once daily (ages 8 to <10 years) or 5-20 mg once daily (ages 10+); HoFH: 20 mg once daily (ages 7+); adults: 5-40 mg once daily.
Myocardial Infarction, Cerebrovascular accident, Angina, Unstable 4 grams per day (four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food) as adjunct to maximally tolerated statin therapy.
Hypertriglyceridemia 4 grams per day (four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food) as adjunct to diet.
Contraindications
- Acute liver failure or decompensated cirrhosis
- Hypersensitivity to rosuvastatin or any excipient in CRESTOR
- Known hypersensitivity (e.g., anaphylactic reaction) to icosapent ethyl or any of its components
Adverse Reactions
Most common (>=2%) headache, nausea, myalgia, asthenia, constipation, arthralgia, dizziness, increased CPK, abdominal pain, diabetes mellitus
Serious myopathy, rhabdomyolysis, immune-mediated necrotizing myopathy, hepatic dysfunction, proteinuria, hematuria, increases in HbA1c and fasting serum glucose
Postmarketing thrombocytopenia, hepatitis, jaundice, hepatic failure, peripheral neuropathy, cognitive impairment, myasthenia gravis, depression, sleep disorders, gynecomastia, interstitial lung disease, DRESS, lichenoid drug eruption
Most common (>=3%) musculoskeletal pain, peripheral edema, constipation, gout, atrial fibrillation
Postmarketing diarrhea, blood triglycerides increased, abdominal discomfort, pain in the extremities
Pharmacology
CRESTOR (rosuvastatin) is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme converting HMG-CoA to mevalonate (a cholesterol precursor); inhibition accelerates hepatic LDL-receptor expression, reducing plasma LDL-C, total cholesterol, and VLDL levels.
Icosapent ethyl (EPA ethyl ester) reduces hepatic VLDL-TG synthesis and/or secretion and enhances TG clearance from circulating VLDL particles, with multi-factorial mechanisms likely contributing to cardiovascular risk reduction.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Crestor
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (0/12)
Vascepa
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (3/12) · Qty limit (9/12)
UnitedHealthcare
Crestor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Vascepa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Crestor
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Vascepa
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Crestor.
No savings programs available for Vascepa.
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CrestorView full Crestor profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.