| Hypoalbuminemia
Flexbumin 5% vs Flexbumin 25%
Side-by-side clinical, coverage, and cost comparison for hypoalbuminemia.Deep comparison between: Flexbumin vs Flexbumin with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsFlexbumin has a higher rate of injection site reactions vs Flexbumin based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Flexbumin but not Flexbumin, including UnitedHealthcare
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Category
Flexbumin
Flexbumin
At A Glance
IV infusion
Human albumin
IV infusion
Human albumin / plasma volume expander
Indications
- Hypoalbuminemia
- Hypoalbuminemia
- Respiratory Distress Syndrome, Adult
- Nephrotic Syndrome
- Erythroblastosis, Fetal
Dosing
Hypoalbuminemia Calculate the body albumin compartment to be 80 to 100 mL per kg body weight; do not exceed a daily dose of 2 g of albumin per kg of body weight; administer IV at no more than 1 mL/min in patients with normal blood volume.
Hypovolemic Shock Infants and young children: 12 to 20 mL per kg body weight IV; older children and adults: initial dose 250 to 500 mL IV, repeated after 15 to 30 minutes if response is inadequate.
Burns Determine dosage according to patient condition and response to treatment after the first 24 hours; administer IV in conjunction with appropriate crystalloid therapy.
Hypovolemia Use 5% protein solutions or dilute 25% albumin with crystalloid solutions in the absence of adequate or excessive hydration; administer IV.
Hypovolemic Shock Infants and young children: 2.5 to 5 mL per kg body weight IV; older children and adults: initial dose 100 to 200 mL IV, repeated after 15 to 30 minutes if response is inadequate. Do not exceed 1 mL/min in patients with normal blood volume.
Hypoalbuminemia Calculate body albumin compartment to be 80 to 100 mL per kg body weight; do not exceed a daily dose of 2 g of albumin per kg of body weight, administered IV.
Burns Dose determined by patient's condition and response to treatment after the first 24 hours, administered IV.
Erythroblastosis, Fetal 1 g per kilogram body weight IV prior to or during exchange transfusion.
Contraindications
- History of hypersensitivity reaction to albumin preparations or to any of the excipients (N-acetyltryptophan and sodium caprylate), including anaphylactic shock, anaphylactic reaction, or hypersensitivity/allergic reactions
- Severe anemia or cardiac failure with normal or increased intravascular volume
- History of hypersensitivity reaction to albumin preparations or to any excipient (N-acetyltryptophan and sodium caprylate)
- Severe anemia or cardiac failure with normal or increased intravascular volume
Adverse Reactions
Serious Anaphylactic shock, anaphylactic reaction, hypersensitivity/allergic reactions, pulmonary edema
Postmarketing Headache, dysgeusia, myocardial infarction, atrial fibrillation, tachycardia, hypotension, flushing, dyspnea, vomiting, nausea, urticaria, rash, pruritus, pyrexia, chills
Serious Hypersensitivity reaction, anaphylactic reaction, pulmonary edema
Postmarketing Anaphylactic shock, anaphylactic reaction, hypersensitivity/allergic reactions, headache, dysgeusia, myocardial infarction, atrial fibrillation, tachycardia, hypotension, flushing, pulmonary edema, dyspnea, vomiting, nausea, urticaria, rash, pruritus, pyrexia, chills
Pharmacology
Human albumin accounts for 70 to 80% of the colloid osmotic pressure of normal plasma, regulating the volume of circulating blood; it also serves as a transport protein binding naturally occurring, therapeutic, and toxic materials in the circulation.
Human albumin accounts for 70 to 80% of the colloid osmotic pressure of normal plasma and serves as a transport protein; administered as a 25% IV solution, it draws approximately 3.5 times its volume of additional fluid into the circulation within 15 minutes, expanding blood volume.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Flexbumin
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
Flexbumin
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Flexbumin
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Flexbumin
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Flexbumin
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Flexbumin
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Flexbumin.
No savings programs available for Flexbumin.
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FlexbuminView full Flexbumin profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.