| Hypogonadotropic hypogonadism
Jatenzo vs Aveed
Side-by-side clinical, coverage, and cost comparison for hypogonadotropic hypogonadism.Deep comparison between: Jatenzo vs Aveed with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAveed has a higher rate of injection site reactions vs Jatenzo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Aveed but not Jatenzo, including UnitedHealthcare
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Category
Jatenzo
Aveed
At A Glance
Oral
Twice daily
Androgen
IM injection
Every 10 weeks
Androgen
Indications
- Primary hypogonadism
- Hypogonadotropic hypogonadism
- Primary hypogonadism
- Hypogonadotropic hypogonadism
- Klinefelter Syndrome
Dosing
Primary hypogonadism, Hypogonadotropic hypogonadism Starting dose 237 mg orally twice daily (morning and evening) with food; dose adjusted between 158 mg and 396 mg twice daily based on serum testosterone concentration measured 6 hours after the morning dose.
Primary hypogonadism, Hypogonadotropic hypogonadism, Klinefelter Syndrome 750 mg (3 mL) IM injection deeply into the gluteal muscle at initiation, repeated after 4 weeks, then every 10 weeks thereafter; observe patients for 30 minutes after each injection.
Contraindications
- Carcinoma of the breast or known or suspected carcinoma of the prostate
- Pregnancy
- Known hypersensitivity to JATENZO or any of its ingredients
- Carcinoma of the breast or known or suspected carcinoma of the prostate
- Pregnancy (testosterone causes virilization of the female fetus)
- Known hypersensitivity to AVEED or any of its ingredients (testosterone undecanoate, refined castor oil, benzyl benzoate)
Adverse Reactions
Most common (>=2%) Headache, hematocrit increased, hypertension, HDL decreased, nausea
Postmarketing Myocardial infarction, stroke, venous thromboembolism
Most common (>2%) Acne, injection site pain, prostatic specific antigen increased, estradiol increased, hypogonadism
Serious Pulmonary oil microembolism (POME), anaphylaxis, blood pressure increases, cardiovascular events including non-fatal arrhythmias, atrial fibrillation, and acute kidney injury
Postmarketing Polycythemia, thrombocytopenia, myocardial infarction, stroke, deep venous thrombosis, pulmonary embolism, prostate cancer, gynecomastia, hepatic function abnormalities
Pharmacology
Testosterone undecanoate is a prodrug ester of testosterone; after oral absorption via intestinal lymphatics, endogenous esterases cleave the ester bond to release active testosterone, which binds androgen receptors to support normal male sexual development and maintenance of secondary sex characteristics.
Testosterone replacement agent; endogenous androgen responsible for normal growth and development of male sex organs and maintenance of secondary sex characteristics including hair distribution, laryngeal enlargement, and body musculature and fat distribution.
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Most Common Insurance
Anthem BCBS
Jatenzo
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (10/12)
Aveed
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (0/12)
UnitedHealthcare
Jatenzo
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Aveed
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Jatenzo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Aveed
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Jatenzo.
$0/fillfill
Aveed Copay Assistance ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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JatenzoView full Jatenzo profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.