| Immune thrombocytopenic purpura
Tavalisse vs Alvaiz
Side-by-side clinical, coverage, and cost comparison for immune thrombocytopenic purpura.Deep comparison between: Tavalisse vs Alvaiz with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAlvaiz has a higher rate of injection site reactions vs Tavalisse based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Alvaiz but not Tavalisse, including UnitedHealthcare
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Category
Tavalisse
Alvaiz
At A Glance
Oral
Twice daily
SYK inhibitor
Oral
Daily
TPO-receptor agonist
Indications
- Immune thrombocytopenic purpura
- Immune thrombocytopenic purpura
- Hepatitis C, Chronic
- Severe Aplastic Anemia
Dosing
Immune thrombocytopenic purpura Initiate at 100 mg orally twice daily; after 4 weeks, increase to 150 mg twice daily if platelet count has not reached at least 50 x 10 9 /L; use the lowest dose to maintain platelet count at least 50 x 10 9 /L; discontinue after 12 weeks if platelet count does not increase sufficiently to avoid clinically important bleeding.
Immune thrombocytopenic purpura Initiate at 36 mg orally once daily (18 mg for East-/Southeast-Asian ancestry or hepatic impairment; 9 mg for both); adjust in 18-mg increments to maintain platelet count >=50 x 10^9/L; maximum 54 mg daily.
Hepatitis C, Chronic Initiate at 18 mg orally once daily; adjust in 18-mg increments every 2 weeks to achieve platelet count needed to initiate or maintain pegylated interferon and ribavirin therapy; maximum 72 mg daily; discontinue when antiviral therapy is discontinued.
Severe Aplastic Anemia Initiate at 36 mg orally once daily (18 mg for East-/Southeast-Asian ancestry or hepatic impairment); adjust in 36-mg increments every 2 weeks to maintain platelet count >=50 x 10^9/L; maximum 108 mg daily.
Contraindications
—
—
Adverse Reactions
Most common (>=5%) Diarrhea, hypertension, nausea, dizziness, ALT increased, AST increased, respiratory infection, rash, abdominal pain, fatigue, chest pain, neutropenia
Serious Febrile neutropenia, diarrhea, pneumonia, hypertensive crisis
Most common (>=3%) Nausea, diarrhea, upper respiratory tract infection, vomiting, urinary tract infection, increased ALT, myalgia, oropharyngeal pain, increased AST, pharyngitis, back pain, influenza, paresthesia, rash
Serious Hemorrhage, thrombotic/thromboembolic complications, hepatic decompensation, hepatotoxicity, cataracts
Postmarketing Skin discoloration including hyperpigmentation and skin yellowing
Pharmacology
Fostamatinib is a tyrosine kinase inhibitor with demonstrated activity against spleen tyrosine kinase (SYK); its major active metabolite R406 inhibits signal transduction of Fc-activating receptors and B-cell receptor, reducing antibody-mediated destruction of platelets.
Eltrombopag is a TPO-receptor agonist that interacts with the transmembrane domain of the human TPO-receptor (cMpl), initiating signaling cascades that induce proliferation and differentiation of megakaryocytes, leading to increased platelet production.
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Most Common Insurance
Anthem BCBS
Tavalisse
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Alvaiz
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (1/12)
UnitedHealthcare
Tavalisse
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (4/8) · Qty limit (5/8)
Alvaiz
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (0/8)
Humana
Tavalisse
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Alvaiz
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$15/fillfill
Tavalisse Copay AssistanceCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availablePAF Co-Pay Relief: Aplastic Anemia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.