| Iron deficiency anemia
Accrufer vs Auryxia
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Accrufer vs Auryxia with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAuryxia has a higher rate of injection site reactions vs Accrufer based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Auryxia but not Accrufer, including UnitedHealthcare
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Category
Accrufer
Auryxia
At A Glance
Oral
Twice daily
Iron replacement
Oral
3 times daily with meals
Phosphate binder; iron replacement
Indications
- Iron deficiency anemia
- Hyperphosphatemia (disorder)
- Iron deficiency anemia
Dosing
Iron deficiency anemia 30 mg orally twice daily on an empty stomach, 1 hour before or 2 hours after meals; swallow capsules whole; treat for at least 12 weeks or until ferritin levels normalize.
Hyperphosphatemia (disorder) Starting dose 2 tablets orally 3 times per day with meals; titrate in increments or decrements of 1 to 2 tablets per day at 1-week or longer intervals; maximum 12 tablets daily.
Iron deficiency anemia Starting dose 1 tablet orally 3 times per day with meals; titrate as needed to achieve and maintain hemoglobin at target levels; maximum 12 tablets daily.
Contraindications
- Hypersensitivity to ferric maltol or any excipient (reactions may include shock, clinically significant hypotension, loss of consciousness, or collapse)
- Hemochromatosis and other iron overload syndromes
- Receiving repeated blood transfusions
- Iron overload syndromes (e.g., hemochromatosis)
Adverse Reactions
Most common (>=1%) flatulence, diarrhea, constipation, feces discolored, abdominal pain, nausea, vomiting, abdominal discomfort, abdominal distension
Serious inflammatory bowel disease flare, iron overload
Most common (>5%) in CKD on dialysis Diarrhea, discolored feces, nausea, constipation, vomiting, cough
Most common (>=5%) in CKD not on dialysis Discolored feces, diarrhea, constipation, nausea, abdominal pain, hyperkalemia
Pharmacology
ACCRUFER (ferric maltol) is an oral ferric iron complex that delivers iron for uptake across the intestinal wall, enabling transfer to transferrin and ferritin to replenish iron stores.
Ferric citrate acts via two mechanisms: ferric iron binds dietary phosphate in the GI tract and precipitates as insoluble ferric phosphate to lower serum phosphorus; and ferric iron is reduced to the ferrous form in the GI tract and absorbed into the blood, where it circulates bound to transferrin and can be incorporated into hemoglobin.
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Most Common Insurance
Anthem BCBS
Accrufer
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (0/12)
Auryxia
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Accrufer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Auryxia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Accrufer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Auryxia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Accrufer.
Cost estimate not availableAssistance Fund: Iron Deficiency Anemia: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.