| Iron deficiency anemia
Accrufer vs Injectafer
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Accrufer vs Injectafer with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsInjectafer has a higher rate of injection site reactions vs Accrufer based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Injectafer but not Accrufer, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Accrufer
Injectafer
At A Glance
Oral
Twice daily
Iron replacement
IV infusion
Two doses, >=7 days apart
IV iron replacement
Indications
- Iron deficiency anemia
- Iron deficiency anemia
- Iron deficiency
Dosing
Iron deficiency anemia 30 mg orally twice daily on an empty stomach, 1 hour before or 2 hours after meals; swallow capsules whole; treat for at least 12 weeks or until ferritin levels normalize.
Iron deficiency anemia For patients >=50 kg: 750 mg IV x2 doses separated by >=7 days (cumulative 1,500 mg per course); alternatively, single dose 15 mg/kg up to 1,000 mg IV per course. For patients <50 kg: 15 mg/kg IV x2 doses separated by >=7 days per course.
Iron deficiency Heart failure (NYHA class II/III): dose based on weight and hemoglobin per label table (Day 1: 500-1,000 mg IV; Week 6: 500-1,000 mg or no dose); maintenance 500 mg IV at weeks 12, 24, and 36 if serum ferritin below threshold.
Contraindications
- Hypersensitivity to ferric maltol or any excipient (reactions may include shock, clinically significant hypotension, loss of consciousness, or collapse)
- Hemochromatosis and other iron overload syndromes
- Receiving repeated blood transfusions
- History of hypersensitivity to Injectafer or any of its components
Adverse Reactions
Most common (>=1%) flatulence, diarrhea, constipation, feces discolored, abdominal pain, nausea, vomiting, abdominal discomfort, abdominal distension
Serious inflammatory bowel disease flare, iron overload
Most common (>=1%) Nausea, hypertension, flushing, injection site reactions, erythema, hypophosphatemia, dizziness, vomiting, injection site discoloration, headache, hepatic enzyme increased, dysgeusia, hypotension, rash
Serious Hypersensitivity reactions, hypophosphatemia, hypertension
Postmarketing Tachycardia, chest discomfort, chills, pyrexia, arthralgia, back pain, hypophosphatemic osteomalacia, syncope, dyspnea, angioedema, pruritus, urticaria, fetal bradycardia
Pharmacology
ACCRUFER (ferric maltol) is an oral ferric iron complex that delivers iron for uptake across the intestinal wall, enabling transfer to transferrin and ferritin to replenish iron stores.
Ferric carboxymaltose is a colloidal iron (III)-hydroxide in complex with carboxymaltose, a carbohydrate polymer that releases iron; after IV administration, iron is incorporated into hemoglobin and iron-storing proteins via the reticuloendothelial system.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Accrufer
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (0/12)
Injectafer
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Accrufer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Injectafer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Accrufer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Injectafer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Accrufer.
No savings programs available for Injectafer.
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
AccruferView full Accrufer profile
InjectaferView full Injectafer profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.