| Iron deficiency anemia
Accrufer vs Venofer
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Accrufer vs Venofer with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVenofer has a higher rate of injection site reactions vs Accrufer based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Venofer but not Accrufer, including UnitedHealthcare
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Category
Accrufer
Venofer
At A Glance
Oral
Twice daily
Iron replacement
IV infusion
IV iron replacement
Indications
- Iron deficiency anemia
- Iron deficiency anemia
Dosing
Iron deficiency anemia 30 mg orally twice daily on an empty stomach, 1 hour before or 2 hours after meals; swallow capsules whole; treat for at least 12 weeks or until ferritin levels normalize.
Iron deficiency anemia (HDD-CKD, adults) 100 mg undiluted by slow IV injection over 2-5 minutes, or diluted in up to 100 mL 0.9% NaCl over at least 15 minutes, per consecutive hemodialysis session; usual total course 1000 mg.
Iron deficiency anemia (NDD-CKD, adults) 200 mg undiluted by slow IV injection over 2-5 minutes or diluted in up to 100 mL 0.9% NaCl over 15 minutes, administered on 5 occasions over 14 days; alternatively 500 mg in up to 250 mL 0.9% NaCl over 3.5-4 hours on Day 1 and Day 14.
Iron deficiency anemia (PDD-CKD, adults) 300 mg IV infusion over 1.5 hours on Day 1 and Day 14, followed by 400 mg IV infusion over 2.5 hours on Day 28, each diluted in up to 250 mL 0.9% NaCl.
Iron deficiency anemia (HDD-CKD, pediatric >= 2 years, maintenance) 0.5 mg/kg (max 100 mg per dose) every 2 weeks for 12 weeks, given by slow IV injection over 5 minutes undiluted or diluted in 0.9% NaCl at 1-2 mg/mL over 5-60 minutes.
Iron deficiency anemia (NDD-CKD or PDD-CKD, pediatric >= 2 years on erythropoietin, maintenance) 0.5 mg/kg (max 100 mg per dose) every 4 weeks for 12 weeks, given by slow IV injection over 5 minutes undiluted or diluted in 0.9% NaCl at 1-2 mg/mL over 5-60 minutes.
Contraindications
- Hypersensitivity to ferric maltol or any excipient (reactions may include shock, clinically significant hypotension, loss of consciousness, or collapse)
- Hemochromatosis and other iron overload syndromes
- Receiving repeated blood transfusions
- Known hypersensitivity to Venofer
Adverse Reactions
Most common (>=1%) flatulence, diarrhea, constipation, feces discolored, abdominal pain, nausea, vomiting, abdominal discomfort, abdominal distension
Serious inflammatory bowel disease flare, iron overload
Most common (>=2%) Hypotension, muscle cramp, nausea, headache, vomiting, dizziness, hypertension, chest pain, diarrhea, peripheral edema, pain in extremity, pruritus, pyrexia, dyspnea
Serious Hypersensitivity reactions, hypotension, iron overload
Postmarketing Anaphylactic-type reactions, angioedema, convulsions, bradycardia, shock, acute myocardial ischemia, bronchospasm, cardiovascular collapse, confusion, loss of consciousness
Pharmacology
ACCRUFER (ferric maltol) is an oral ferric iron complex that delivers iron for uptake across the intestinal wall, enabling transfer to transferrin and ferritin to replenish iron stores.
Venofer is an aqueous complex of polynuclear iron (III)-hydroxide in sucrose; following IV administration it dissociates into iron and sucrose, with iron transported via transferrin to erythroid precursor cells where it is incorporated into hemoglobin as cells mature into red blood cells.
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Most Common Insurance
Anthem BCBS
Accrufer
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (0/12)
Venofer
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Accrufer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Venofer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Accrufer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Venofer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Accrufer.
No savings programs available for Venofer.
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AccruferView full Accrufer profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.