| Iron deficiency anemia
Auryxia vs Feraheme
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Auryxia vs Feraheme with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsFeraheme has a higher rate of injection site reactions vs Auryxia based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Feraheme but not Auryxia, including UnitedHealthcare
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Category
Auryxia
Feraheme
At A Glance
Oral
3 times daily with meals
Phosphate binder; iron replacement
IV infusion
Two doses, 3-8 days apart
Iron replacement
Indications
- Hyperphosphatemia (disorder)
- Iron deficiency anemia
- Iron deficiency anemia
Dosing
Hyperphosphatemia (disorder) Starting dose 2 tablets orally 3 times per day with meals; titrate in increments or decrements of 1 to 2 tablets per day at 1-week or longer intervals; maximum 12 tablets daily.
Iron deficiency anemia Starting dose 1 tablet orally 3 times per day with meals; titrate as needed to achieve and maintain hemoglobin at target levels; maximum 12 tablets daily.
Iron deficiency anemia 510 mg IV infusion initial dose, followed by a second 510 mg dose 3 to 8 days later, administered in 50-200 mL 0.9% Sodium Chloride or 5% Dextrose over at least 15 minutes.
Contraindications
- Iron overload syndromes (e.g., hemochromatosis)
- Known hypersensitivity to Feraheme or any of its components
- History of allergic reaction to any intravenous iron product
Adverse Reactions
Most common (>5%) in CKD on dialysis Diarrhea, discolored feces, nausea, constipation, vomiting, cough
Most common (>=5%) in CKD not on dialysis Discolored feces, diarrhea, constipation, nausea, abdominal pain, hyperkalemia
Most common (>=1%) Headache, nausea, dizziness, fatigue, diarrhea, back pain
Serious Serious hypersensitivity reactions, hypotension, iron overload, MR imaging test interference
Postmarketing Fatal and life-threatening anaphylactic-type reactions, acute myocardial ischemia, cardiac/cardiorespiratory arrest, clinically significant hypotension, syncope, angioedema, congestive heart failure, cyanosis
Pharmacology
Ferric citrate acts via two mechanisms: ferric iron binds dietary phosphate in the GI tract and precipitates as insoluble ferric phosphate to lower serum phosphorus; and ferric iron is reduced to the ferrous form in the GI tract and absorbed into the blood, where it circulates bound to transferrin and can be incorporated into hemoglobin.
Intravenous iron replacement agent; ferumoxytol is a superparamagnetic iron oxide coated with a carbohydrate shell that releases bioactive iron via reticuloendothelial system macrophages for incorporation into hemoglobin.
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Most Common Insurance
Anthem BCBS
Auryxia
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
Feraheme
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (9/12)
UnitedHealthcare
Auryxia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Feraheme
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Auryxia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Feraheme
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Iron Deficiency Anemia: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Iron Deficiency Anemia: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.