| Iron deficiency anemia
Feraheme vs Injectafer
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Feraheme vs Injectafer with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsInjectafer has a higher rate of injection site reactions vs Feraheme based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Injectafer but not Feraheme, including UnitedHealthcare
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Category
Feraheme
Injectafer
At A Glance
IV infusion
Two doses, 3-8 days apart
Iron replacement
IV infusion
Two doses, >=7 days apart
IV iron replacement
Indications
- Iron deficiency anemia
- Iron deficiency anemia
- Iron deficiency
Dosing
Iron deficiency anemia 510 mg IV infusion initial dose, followed by a second 510 mg dose 3 to 8 days later, administered in 50-200 mL 0.9% Sodium Chloride or 5% Dextrose over at least 15 minutes.
Iron deficiency anemia For patients >=50 kg: 750 mg IV x2 doses separated by >=7 days (cumulative 1,500 mg per course); alternatively, single dose 15 mg/kg up to 1,000 mg IV per course. For patients <50 kg: 15 mg/kg IV x2 doses separated by >=7 days per course.
Iron deficiency Heart failure (NYHA class II/III): dose based on weight and hemoglobin per label table (Day 1: 500-1,000 mg IV; Week 6: 500-1,000 mg or no dose); maintenance 500 mg IV at weeks 12, 24, and 36 if serum ferritin below threshold.
Contraindications
- Known hypersensitivity to Feraheme or any of its components
- History of allergic reaction to any intravenous iron product
- History of hypersensitivity to Injectafer or any of its components
Adverse Reactions
Most common (>=1%) Headache, nausea, dizziness, fatigue, diarrhea, back pain
Serious Serious hypersensitivity reactions, hypotension, iron overload, MR imaging test interference
Postmarketing Fatal and life-threatening anaphylactic-type reactions, acute myocardial ischemia, cardiac/cardiorespiratory arrest, clinically significant hypotension, syncope, angioedema, congestive heart failure, cyanosis
Most common (>=1%) Nausea, hypertension, flushing, injection site reactions, erythema, hypophosphatemia, dizziness, vomiting, injection site discoloration, headache, hepatic enzyme increased, dysgeusia, hypotension, rash
Serious Hypersensitivity reactions, hypophosphatemia, hypertension
Postmarketing Tachycardia, chest discomfort, chills, pyrexia, arthralgia, back pain, hypophosphatemic osteomalacia, syncope, dyspnea, angioedema, pruritus, urticaria, fetal bradycardia
Pharmacology
Intravenous iron replacement agent; ferumoxytol is a superparamagnetic iron oxide coated with a carbohydrate shell that releases bioactive iron via reticuloendothelial system macrophages for incorporation into hemoglobin.
Ferric carboxymaltose is a colloidal iron (III)-hydroxide in complex with carboxymaltose, a carbohydrate polymer that releases iron; after IV administration, iron is incorporated into hemoglobin and iron-storing proteins via the reticuloendothelial system.
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Most Common Insurance
Anthem BCBS
Feraheme
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (9/12)
Injectafer
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Feraheme
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Injectafer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Feraheme
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Injectafer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Iron Deficiency Anemia: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Injectafer.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.