| Iron deficiency anemia
Feraheme vs Venofer
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Feraheme vs Venofer with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVenofer has a higher rate of injection site reactions vs Feraheme based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Venofer but not Feraheme, including UnitedHealthcare
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Category
Feraheme
Venofer
At A Glance
IV infusion
Two doses, 3-8 days apart
Iron replacement
IV infusion
IV iron replacement
Indications
- Iron deficiency anemia
- Iron deficiency anemia
Dosing
Iron deficiency anemia 510 mg IV infusion initial dose, followed by a second 510 mg dose 3 to 8 days later, administered in 50-200 mL 0.9% Sodium Chloride or 5% Dextrose over at least 15 minutes.
Iron deficiency anemia (HDD-CKD, adults) 100 mg undiluted by slow IV injection over 2-5 minutes, or diluted in up to 100 mL 0.9% NaCl over at least 15 minutes, per consecutive hemodialysis session; usual total course 1000 mg.
Iron deficiency anemia (NDD-CKD, adults) 200 mg undiluted by slow IV injection over 2-5 minutes or diluted in up to 100 mL 0.9% NaCl over 15 minutes, administered on 5 occasions over 14 days; alternatively 500 mg in up to 250 mL 0.9% NaCl over 3.5-4 hours on Day 1 and Day 14.
Iron deficiency anemia (PDD-CKD, adults) 300 mg IV infusion over 1.5 hours on Day 1 and Day 14, followed by 400 mg IV infusion over 2.5 hours on Day 28, each diluted in up to 250 mL 0.9% NaCl.
Iron deficiency anemia (HDD-CKD, pediatric >= 2 years, maintenance) 0.5 mg/kg (max 100 mg per dose) every 2 weeks for 12 weeks, given by slow IV injection over 5 minutes undiluted or diluted in 0.9% NaCl at 1-2 mg/mL over 5-60 minutes.
Iron deficiency anemia (NDD-CKD or PDD-CKD, pediatric >= 2 years on erythropoietin, maintenance) 0.5 mg/kg (max 100 mg per dose) every 4 weeks for 12 weeks, given by slow IV injection over 5 minutes undiluted or diluted in 0.9% NaCl at 1-2 mg/mL over 5-60 minutes.
Contraindications
- Known hypersensitivity to Feraheme or any of its components
- History of allergic reaction to any intravenous iron product
- Known hypersensitivity to Venofer
Adverse Reactions
Most common (>=1%) Headache, nausea, dizziness, fatigue, diarrhea, back pain
Serious Serious hypersensitivity reactions, hypotension, iron overload, MR imaging test interference
Postmarketing Fatal and life-threatening anaphylactic-type reactions, acute myocardial ischemia, cardiac/cardiorespiratory arrest, clinically significant hypotension, syncope, angioedema, congestive heart failure, cyanosis
Most common (>=2%) Hypotension, muscle cramp, nausea, headache, vomiting, dizziness, hypertension, chest pain, diarrhea, peripheral edema, pain in extremity, pruritus, pyrexia, dyspnea
Serious Hypersensitivity reactions, hypotension, iron overload
Postmarketing Anaphylactic-type reactions, angioedema, convulsions, bradycardia, shock, acute myocardial ischemia, bronchospasm, cardiovascular collapse, confusion, loss of consciousness
Pharmacology
Intravenous iron replacement agent; ferumoxytol is a superparamagnetic iron oxide coated with a carbohydrate shell that releases bioactive iron via reticuloendothelial system macrophages for incorporation into hemoglobin.
Venofer is an aqueous complex of polynuclear iron (III)-hydroxide in sucrose; following IV administration it dissociates into iron and sucrose, with iron transported via transferrin to erythroid precursor cells where it is incorporated into hemoglobin as cells mature into red blood cells.
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Most Common Insurance
Anthem BCBS
Feraheme
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (9/12)
Venofer
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Feraheme
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Venofer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Feraheme
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Venofer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Iron Deficiency Anemia: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Venofer.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.