| Iron deficiency anemia
Injectafer vs Auryxia
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Injectafer vs Auryxia with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAuryxia has a higher rate of injection site reactions vs Injectafer based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Auryxia but not Injectafer, including UnitedHealthcare
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Category
Injectafer
Auryxia
At A Glance
IV infusion
Two doses, >=7 days apart
IV iron replacement
Oral
3 times daily with meals
Phosphate binder; iron replacement
Indications
- Iron deficiency anemia
- Iron deficiency
- Hyperphosphatemia (disorder)
- Iron deficiency anemia
Dosing
Iron deficiency anemia For patients >=50 kg: 750 mg IV x2 doses separated by >=7 days (cumulative 1,500 mg per course); alternatively, single dose 15 mg/kg up to 1,000 mg IV per course. For patients <50 kg: 15 mg/kg IV x2 doses separated by >=7 days per course.
Iron deficiency Heart failure (NYHA class II/III): dose based on weight and hemoglobin per label table (Day 1: 500-1,000 mg IV; Week 6: 500-1,000 mg or no dose); maintenance 500 mg IV at weeks 12, 24, and 36 if serum ferritin below threshold.
Hyperphosphatemia (disorder) Starting dose 2 tablets orally 3 times per day with meals; titrate in increments or decrements of 1 to 2 tablets per day at 1-week or longer intervals; maximum 12 tablets daily.
Iron deficiency anemia Starting dose 1 tablet orally 3 times per day with meals; titrate as needed to achieve and maintain hemoglobin at target levels; maximum 12 tablets daily.
Contraindications
- History of hypersensitivity to Injectafer or any of its components
- Iron overload syndromes (e.g., hemochromatosis)
Adverse Reactions
Most common (>=1%) Nausea, hypertension, flushing, injection site reactions, erythema, hypophosphatemia, dizziness, vomiting, injection site discoloration, headache, hepatic enzyme increased, dysgeusia, hypotension, rash
Serious Hypersensitivity reactions, hypophosphatemia, hypertension
Postmarketing Tachycardia, chest discomfort, chills, pyrexia, arthralgia, back pain, hypophosphatemic osteomalacia, syncope, dyspnea, angioedema, pruritus, urticaria, fetal bradycardia
Most common (>5%) in CKD on dialysis Diarrhea, discolored feces, nausea, constipation, vomiting, cough
Most common (>=5%) in CKD not on dialysis Discolored feces, diarrhea, constipation, nausea, abdominal pain, hyperkalemia
Pharmacology
Ferric carboxymaltose is a colloidal iron (III)-hydroxide in complex with carboxymaltose, a carbohydrate polymer that releases iron; after IV administration, iron is incorporated into hemoglobin and iron-storing proteins via the reticuloendothelial system.
Ferric citrate acts via two mechanisms: ferric iron binds dietary phosphate in the GI tract and precipitates as insoluble ferric phosphate to lower serum phosphorus; and ferric iron is reduced to the ferrous form in the GI tract and absorbed into the blood, where it circulates bound to transferrin and can be incorporated into hemoglobin.
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Most Common Insurance
Anthem BCBS
Injectafer
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Auryxia
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Injectafer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Auryxia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Injectafer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Auryxia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Injectafer.
Cost estimate not availableAssistance Fund: Iron Deficiency Anemia: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.