| Iron deficiency anemia
Injectafer vs Venofer
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Injectafer vs Venofer with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVenofer has a higher rate of injection site reactions vs Injectafer based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Venofer but not Injectafer, including UnitedHealthcare
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Category
Injectafer
Venofer
At A Glance
IV infusion
Two doses, >=7 days apart
IV iron replacement
IV infusion
IV iron replacement
Indications
- Iron deficiency anemia
- Iron deficiency
- Iron deficiency anemia
Dosing
Iron deficiency anemia For patients >=50 kg: 750 mg IV x2 doses separated by >=7 days (cumulative 1,500 mg per course); alternatively, single dose 15 mg/kg up to 1,000 mg IV per course. For patients <50 kg: 15 mg/kg IV x2 doses separated by >=7 days per course.
Iron deficiency Heart failure (NYHA class II/III): dose based on weight and hemoglobin per label table (Day 1: 500-1,000 mg IV; Week 6: 500-1,000 mg or no dose); maintenance 500 mg IV at weeks 12, 24, and 36 if serum ferritin below threshold.
Iron deficiency anemia (HDD-CKD, adults) 100 mg undiluted by slow IV injection over 2-5 minutes, or diluted in up to 100 mL 0.9% NaCl over at least 15 minutes, per consecutive hemodialysis session; usual total course 1000 mg.
Iron deficiency anemia (NDD-CKD, adults) 200 mg undiluted by slow IV injection over 2-5 minutes or diluted in up to 100 mL 0.9% NaCl over 15 minutes, administered on 5 occasions over 14 days; alternatively 500 mg in up to 250 mL 0.9% NaCl over 3.5-4 hours on Day 1 and Day 14.
Iron deficiency anemia (PDD-CKD, adults) 300 mg IV infusion over 1.5 hours on Day 1 and Day 14, followed by 400 mg IV infusion over 2.5 hours on Day 28, each diluted in up to 250 mL 0.9% NaCl.
Iron deficiency anemia (HDD-CKD, pediatric >= 2 years, maintenance) 0.5 mg/kg (max 100 mg per dose) every 2 weeks for 12 weeks, given by slow IV injection over 5 minutes undiluted or diluted in 0.9% NaCl at 1-2 mg/mL over 5-60 minutes.
Iron deficiency anemia (NDD-CKD or PDD-CKD, pediatric >= 2 years on erythropoietin, maintenance) 0.5 mg/kg (max 100 mg per dose) every 4 weeks for 12 weeks, given by slow IV injection over 5 minutes undiluted or diluted in 0.9% NaCl at 1-2 mg/mL over 5-60 minutes.
Contraindications
- History of hypersensitivity to Injectafer or any of its components
- Known hypersensitivity to Venofer
Adverse Reactions
Most common (>=1%) Nausea, hypertension, flushing, injection site reactions, erythema, hypophosphatemia, dizziness, vomiting, injection site discoloration, headache, hepatic enzyme increased, dysgeusia, hypotension, rash
Serious Hypersensitivity reactions, hypophosphatemia, hypertension
Postmarketing Tachycardia, chest discomfort, chills, pyrexia, arthralgia, back pain, hypophosphatemic osteomalacia, syncope, dyspnea, angioedema, pruritus, urticaria, fetal bradycardia
Most common (>=2%) Hypotension, muscle cramp, nausea, headache, vomiting, dizziness, hypertension, chest pain, diarrhea, peripheral edema, pain in extremity, pruritus, pyrexia, dyspnea
Serious Hypersensitivity reactions, hypotension, iron overload
Postmarketing Anaphylactic-type reactions, angioedema, convulsions, bradycardia, shock, acute myocardial ischemia, bronchospasm, cardiovascular collapse, confusion, loss of consciousness
Pharmacology
Ferric carboxymaltose is a colloidal iron (III)-hydroxide in complex with carboxymaltose, a carbohydrate polymer that releases iron; after IV administration, iron is incorporated into hemoglobin and iron-storing proteins via the reticuloendothelial system.
Venofer is an aqueous complex of polynuclear iron (III)-hydroxide in sucrose; following IV administration it dissociates into iron and sucrose, with iron transported via transferrin to erythroid precursor cells where it is incorporated into hemoglobin as cells mature into red blood cells.
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Most Common Insurance
Anthem BCBS
Injectafer
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Venofer
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Injectafer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Venofer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Injectafer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Venofer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Injectafer.
No savings programs available for Venofer.
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InjectaferView full Injectafer profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.