| Iron deficiency anemia
Venofer vs Auryxia
Side-by-side clinical, coverage, and cost comparison for iron deficiency anemia.Deep comparison between: Venofer vs Auryxia with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAuryxia has a higher rate of injection site reactions vs Venofer based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Auryxia but not Venofer, including UnitedHealthcare
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Category
Venofer
Auryxia
At A Glance
IV infusion
IV iron replacement
Oral
3 times daily with meals
Phosphate binder; iron replacement
Indications
- Iron deficiency anemia
- Hyperphosphatemia (disorder)
- Iron deficiency anemia
Dosing
Iron deficiency anemia (HDD-CKD, adults) 100 mg undiluted by slow IV injection over 2-5 minutes, or diluted in up to 100 mL 0.9% NaCl over at least 15 minutes, per consecutive hemodialysis session; usual total course 1000 mg.
Iron deficiency anemia (NDD-CKD, adults) 200 mg undiluted by slow IV injection over 2-5 minutes or diluted in up to 100 mL 0.9% NaCl over 15 minutes, administered on 5 occasions over 14 days; alternatively 500 mg in up to 250 mL 0.9% NaCl over 3.5-4 hours on Day 1 and Day 14.
Iron deficiency anemia (PDD-CKD, adults) 300 mg IV infusion over 1.5 hours on Day 1 and Day 14, followed by 400 mg IV infusion over 2.5 hours on Day 28, each diluted in up to 250 mL 0.9% NaCl.
Iron deficiency anemia (HDD-CKD, pediatric >= 2 years, maintenance) 0.5 mg/kg (max 100 mg per dose) every 2 weeks for 12 weeks, given by slow IV injection over 5 minutes undiluted or diluted in 0.9% NaCl at 1-2 mg/mL over 5-60 minutes.
Iron deficiency anemia (NDD-CKD or PDD-CKD, pediatric >= 2 years on erythropoietin, maintenance) 0.5 mg/kg (max 100 mg per dose) every 4 weeks for 12 weeks, given by slow IV injection over 5 minutes undiluted or diluted in 0.9% NaCl at 1-2 mg/mL over 5-60 minutes.
Hyperphosphatemia (disorder) Starting dose 2 tablets orally 3 times per day with meals; titrate in increments or decrements of 1 to 2 tablets per day at 1-week or longer intervals; maximum 12 tablets daily.
Iron deficiency anemia Starting dose 1 tablet orally 3 times per day with meals; titrate as needed to achieve and maintain hemoglobin at target levels; maximum 12 tablets daily.
Contraindications
- Known hypersensitivity to Venofer
- Iron overload syndromes (e.g., hemochromatosis)
Adverse Reactions
Most common (>=2%) Hypotension, muscle cramp, nausea, headache, vomiting, dizziness, hypertension, chest pain, diarrhea, peripheral edema, pain in extremity, pruritus, pyrexia, dyspnea
Serious Hypersensitivity reactions, hypotension, iron overload
Postmarketing Anaphylactic-type reactions, angioedema, convulsions, bradycardia, shock, acute myocardial ischemia, bronchospasm, cardiovascular collapse, confusion, loss of consciousness
Most common (>5%) in CKD on dialysis Diarrhea, discolored feces, nausea, constipation, vomiting, cough
Most common (>=5%) in CKD not on dialysis Discolored feces, diarrhea, constipation, nausea, abdominal pain, hyperkalemia
Pharmacology
Venofer is an aqueous complex of polynuclear iron (III)-hydroxide in sucrose; following IV administration it dissociates into iron and sucrose, with iron transported via transferrin to erythroid precursor cells where it is incorporated into hemoglobin as cells mature into red blood cells.
Ferric citrate acts via two mechanisms: ferric iron binds dietary phosphate in the GI tract and precipitates as insoluble ferric phosphate to lower serum phosphorus; and ferric iron is reduced to the ferrous form in the GI tract and absorbed into the blood, where it circulates bound to transferrin and can be incorporated into hemoglobin.
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Most Common Insurance
Anthem BCBS
Venofer
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Auryxia
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Venofer
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Auryxia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Venofer
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Auryxia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Venofer.
Cost estimate not availableAssistance Fund: Iron Deficiency Anemia: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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VenoferView full Venofer profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.