| Keratoconjunctivitis Sicca
Lacrisert vs Restasis
Side-by-side clinical, coverage, and cost comparison for keratoconjunctivitis sicca.Deep comparison between: Lacrisert vs Restasis with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRestasis has a higher rate of injection site reactions vs Lacrisert based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Restasis but not Lacrisert, including UnitedHealthcare
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Category
Lacrisert
Restasis
At A Glance
Ophthalmic insert
Once daily
Ocular lubricant
Ophthalmic
Twice daily
Calcineurin inhibitor immunosuppressant
Indications
- Dry Eye Syndromes
- Keratoconjunctivitis Sicca
- Exposure keratoconjunctivitis
- Corneal hypoesthesia
- Recurrent erosion of cornea
- Keratoconjunctivitis Sicca
Dosing
Dry Eye Syndromes, Keratoconjunctivitis Sicca, Exposure keratoconjunctivitis, Corneal hypoesthesia, Recurrent erosion of cornea One ophthalmic insert in each eye once daily; some patients may require twice daily use for optimal results; insert into the inferior cul-de-sac of the eye beneath the base of the tarsus.
Keratoconjunctivitis Sicca Instill one drop twice daily in each eye approximately 12 hours apart; may be used concomitantly with lubricant eye drops, allowing a 15-minute interval between products; discard vial immediately after use.
Contraindications
- Hypersensitivity to hydroxypropyl cellulose
- Known or suspected hypersensitivity to any of the ingredients in the formulation
Adverse Reactions
Most common Transient blurring of vision, ocular discomfort or irritation, matting or stickiness of eyelashes, photophobia, hypersensitivity, edema of the eyelids, hyperemia
Most common (>=1%) Ocular burning, conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, visual disturbance
Serious Potential for eye injury and contamination
Postmarketing Hypersensitivity (eye swelling, urticaria, angioedema, face swelling, tongue swelling, pharyngeal edema, dyspnea), superficial eye injury
Pharmacology
Ocular lubricant; stabilizes and thickens the precorneal tear film and prolongs tear film breakup time to reduce signs and symptoms of dry eye syndromes, including lubrication and protection of the eye.
Cyclosporine is an immunosuppressive agent when administered systemically; when applied topically as an ophthalmic emulsion, it is thought to act as a partial immunomodulator in patients whose tear production is suppressed due to ocular inflammation associated with keratoconjunctivitis sicca, though the exact mechanism of action is not known.
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Most Common Insurance
Anthem BCBS
Lacrisert
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
Restasis
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (4/12)
UnitedHealthcare
Lacrisert
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Restasis
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (3/8)
Humana
Lacrisert
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Restasis
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Lacrisert.
No savings programs available for Restasis.
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LacrisertView full Lacrisert profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.