| Lennox-Gastaut Syndrome
Banzel vs Fintepla
Side-by-side clinical, coverage, and cost comparison for lennox-gastaut syndrome.Deep comparison between: Banzel vs Fintepla with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsFintepla has a higher rate of injection site reactions vs Banzel based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Fintepla but not Banzel, including UnitedHealthcare
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Category
Banzel
Fintepla
At A Glance
Oral
Twice daily
Sodium channel modulator
Oral
Twice daily
5-HT2 receptor agonist
Indications
- Lennox-Gastaut Syndrome
- Infantile Severe Myoclonic Epilepsy
- Lennox-Gastaut syndrome
Dosing
Lennox-Gastaut Syndrome (pediatric, 1 to <17 years) Starting dose approximately 10 mg/kg/day in two divided doses; increase by 10 mg/kg every other day to maximum 45 mg/kg/day (not to exceed 3200 mg/day); administer with food.
Lennox-Gastaut Syndrome (adults, >=17 years) Starting dose 400-800 mg/day in two divided doses; increase by 400-800 mg every other day to maximum 3200 mg/day; administer with food.
Infantile Severe Myoclonic Epilepsy, Lennox-Gastaut syndrome Initial 0.1 mg/kg twice daily orally, titrated weekly; maintenance up to 0.35 mg/kg twice daily (max 26 mg/day); with concomitant stiripentol plus clobazam, maximum 0.2 mg/kg twice daily (max 17 mg/day).
Contraindications
- Familial Short QT syndrome
- Hypersensitivity to fenfluramine or any of the excipients in FINTEPLA
- Concomitant use, or within 14 days of administration, of monoamine oxidase inhibitors
Adverse Reactions
Most common (>=10%) Headache, dizziness, fatigue, somnolence, nausea
Serious Suicidal behavior and ideation, CNS reactions, QT shortening, multi-organ hypersensitivity/DRESS, leukopenia
Postmarketing Stevens-Johnson syndrome and other serious skin rashes with mucosal involvement
Most common (>=10%) Decreased appetite, somnolence/sedation/lethargy, diarrhea, fatigue/malaise/asthenia, abnormal echocardiogram, ataxia/balance disorder/gait disturbance, blood pressure increased, drooling/salivary hypersecretion, pyrexia, upper respiratory tract infection, vomiting, weight decreased
Serious Valvular heart disease, pulmonary arterial hypertension, decreased appetite and decreased weight, somnolence/sedation/lethargy, suicidal behavior and ideation, serotonin syndrome, increase in blood pressure, glaucoma, status epilepticus
Postmarketing Aggression
Pharmacology
Rufinamide is an antiepileptic triazole derivative whose principal mechanism of action is modulation of sodium channel activity, specifically prolonging the inactive state of the channel to limit sustained repetitive neuronal firing.
Fenfluramine and its metabolite norfenfluramine exhibit agonist activity at serotonin 5-HT2 receptors; the precise mechanism by which this produces antiseizure effects in Dravet syndrome and Lennox-Gastaut syndrome is unknown, though 5-HT2B receptor agonism is associated with valvular heart disease and pulmonary arterial hypertension risk.
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Most Common Insurance
Anthem BCBS
Banzel
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (0/12)
Fintepla
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (11/12) · Qty limit (9/12)
UnitedHealthcare
Banzel
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (0/8)
Fintepla
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (4/8) · Qty limit (2/8)
Humana
Banzel
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Fintepla
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Epilepsy (Seizures): Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$25
ONWARD Copay Assistance Program: FinteplaCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.