| Macular retinal edema
Lucentis vs Xipere
Side-by-side clinical, coverage, and cost comparison for macular retinal edema.Deep comparison between: Lucentis vs Xipere with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXipere has a higher rate of injection site reactions vs Lucentis based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xipere but not Lucentis, including UnitedHealthcare
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Category
Lucentis
Xipere
At A Glance
Intravitreal injection
Monthly
VEGF-A antagonist
Suprachoroidal injection
Corticosteroid
Indications
- Exudative age-related macular degeneration
- Macular retinal edema
- Macular edema due to diabetes mellitus
- Diabetic Retinopathy
- Myopic choroidal neovascularization
- Macular retinal edema
- Uveitis
Dosing
Exudative age-related macular degeneration 0.5 mg (0.05 mL of 10 mg/mL) intravitreal injection once monthly; less frequent dosing with regular assessment may be considered after 3-4 initial monthly doses.
Macular retinal edema 0.5 mg (0.05 mL of 10 mg/mL) intravitreal injection once monthly.
Macular edema due to diabetes mellitus, Diabetic Retinopathy 0.3 mg (0.05 mL of 6 mg/mL) intravitreal injection once monthly.
Myopic choroidal neovascularization 0.5 mg (0.05 mL of 10 mg/mL) intravitreal injection once monthly for up to 3 months; retreat as needed.
Macular retinal edema, Uveitis 4 mg (0.1 mL) administered as a suprachoroidal injection using the SCS Microinjector.
Contraindications
- Ocular or periocular infections
- Known hypersensitivity to ranibizumab or any excipient in LUCENTIS
- Active or suspected ocular or periocular infections, including active epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, mycobacterial infections, and fungal diseases
- Known hypersensitivity to triamcinolone acetonide or any other components of this product
Adverse Reactions
Most common Conjunctival hemorrhage, eye pain, vitreous floaters, increased intraocular pressure, vitreous detachment, intraocular inflammation, cataract, foreign body sensation in eyes, eye irritation, lacrimation increased, nasopharyngitis, headache
Serious Endophthalmitis, retinal detachment, rhegmatogenous retinal detachment, iatrogenic traumatic cataract, thromboembolic events, fatal events in patients with DME and DR
Postmarketing Tear of retinal pigment epithelium in patients with neovascular AMD
Most common (>=10%) Elevated intraocular pressure, eye pain
Pharmacology
Ranibizumab is a VEGF-A antagonist; a recombinant humanized IgG1 kappa monoclonal antibody fragment that binds to active forms of VEGF-A, preventing interaction with VEGFR1 and VEGFR2 on endothelial cells, thereby reducing endothelial cell proliferation, vascular leakage, and new blood vessel formation.
Triamcinolone acetonide is a synthetic glucocorticoid with immunosuppressive and anti-inflammatory activity; its primary mechanism of action is as a corticosteroid hormone receptor agonist.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Lucentis
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (4/12) · Qty limit (0/12)
Xipere
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Lucentis
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Xipere
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Lucentis
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Xipere
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Inherited Retinal Diseases - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Inherited Retinal Diseases - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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LucentisView full Lucentis profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.