| Macular retinal edema
Ozurdex vs Xipere
Side-by-side clinical, coverage, and cost comparison for macular retinal edema.Deep comparison between: Ozurdex vs Xipere with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXipere has a higher rate of injection site reactions vs Ozurdex based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xipere but not Ozurdex, including UnitedHealthcare
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Category
Ozurdex
Xipere
At A Glance
Intravitreal injection
Corticosteroid
Suprachoroidal injection
Corticosteroid
Indications
- Macular retinal edema
- Uveitis
- Macular retinal edema
- Uveitis
Dosing
Macular retinal edema, Uveitis One 0.7 mg intravitreal implant injected into the vitreous cavity under controlled aseptic conditions; each applicator is single-use and treats one eye only.
Macular retinal edema, Uveitis 4 mg (0.1 mL) administered as a suprachoroidal injection using the SCS Microinjector.
Contraindications
- Active or suspected ocular or periocular infections, including viral diseases of the cornea and conjunctiva (active epithelial herpes simplex keratitis, vaccinia, varicella), mycobacterial infections, and fungal diseases
- Glaucoma with cup to disc ratios greater than 0.8
- Torn or ruptured posterior lens capsule due to risk of migration into the anterior chamber
- Known hypersensitivity to any components of this product
- Active or suspected ocular or periocular infections, including active epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, mycobacterial infections, and fungal diseases
- Known hypersensitivity to triamcinolone acetonide or any other components of this product
Adverse Reactions
Most common (>=20%) Cataract, increased intraocular pressure, conjunctival hemorrhage
Serious Elevated IOP with optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection (including herpes simplex), globe perforation
Postmarketing Endophthalmitis, retinal detachment, implant misplacement with ocular tissue injury, device dislocation with corneal edema or decompensation, hypotony of the eye
Most common (>=10%) Elevated intraocular pressure, eye pain
Pharmacology
Dexamethasone is a corticosteroid that suppresses inflammation by inhibiting multiple inflammatory cytokines, resulting in decreased edema, fibrin deposition, capillary leakage, and migration of inflammatory cells.
Triamcinolone acetonide is a synthetic glucocorticoid with immunosuppressive and anti-inflammatory activity; its primary mechanism of action is as a corticosteroid hormone receptor agonist.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Ozurdex
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
Xipere
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Ozurdex
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Xipere
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Ozurdex
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Xipere
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Ozurdex.
Cost estimate not availableAccessia Health: Inherited Retinal Diseases - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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OzurdexView full Ozurdex profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.