| Malignant neoplasm of prostate
Firmagon vs Posluma
Side-by-side clinical, coverage, and cost comparison for malignant neoplasm of prostate.Deep comparison between: Firmagon vs Posluma with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsPosluma has a higher rate of injection site reactions vs Firmagon based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Posluma but not Firmagon, including UnitedHealthcare
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Category
Firmagon
Posluma
At A Glance
SC injection
Every 28 days
GnRH receptor antagonist
IV injection
PSMA-targeted radiodiagnostic
Indications
- Malignant neoplasm of prostate
- Malignant neoplasm of prostate
Dosing
Malignant neoplasm of prostate Starting dose: 240 mg given as two SC injections of 120 mg each at 40 mg/mL; maintenance dose: 80 mg given as one SC injection at 20 mg/mL every 28 days beginning 28 days after the starting dose.
Malignant neoplasm of prostate 296 MBq (8 mCi) as a single intravenous bolus injection; begin imaging approximately 60 minutes after administration from mid-thigh to base of skull.
Contraindications
- History of severe hypersensitivity to degarelix or any product component
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Adverse Reactions
Most common (>=10%) Injection site reactions (pain, erythema, swelling, induration), hot flashes, increases in serum transaminases and GGT
Postmarketing Decreased bone density
Most common (>=0.4%) Diarrhea, blood pressure increase, injection site pain
Pharmacology
GnRH receptor antagonist; degarelix binds reversibly to pituitary GnRH receptors, reducing the release of gonadotropins and consequently suppressing testosterone below the castration level of 50 ng/dL.
PSMA-targeted radiodiagnostic agent; flotufolastat F 18 binds to PSMA (IC50 = 4.4 nM) on prostate cancer cells, which overexpress PSMA, and is internalized; fluorine-18 emits positrons detectable by PET.
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Most Common Insurance
Anthem BCBS
Firmagon
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (10/12)
No coverage data available for Posluma.
UnitedHealthcare
Firmagon
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (2/8)
No coverage data available for Posluma.
Humana
Firmagon
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
No coverage data available for Posluma.
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Prostate Cancer
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Posluma.
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FirmagonView full Firmagon profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.