| Mantle cell lymphoma
Tecartus vs Calquence Tablets
Side-by-side clinical, coverage, and cost comparison for mantle cell lymphoma.Deep comparison between: Tecartus vs Calquence with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCalquence has a higher rate of injection site reactions vs Tecartus based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Calquence but not Tecartus, including UnitedHealthcare
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Category
Tecartus
Calquence
At A Glance
IV infusion
Single infusion
CD19-directed CAR-T cell therapy
Oral
Every 12 hours
BTK inhibitor
Indications
- Mantle cell lymphoma
- Precursor B-cell lymphoblastic leukemia
- Mantle cell lymphoma
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Lymphoma
Dosing
Mantle cell lymphoma Single IV infusion at 2 x 10^6 CAR-positive viable T cells/kg (max 2 x 10^8 cells) following lymphodepleting chemotherapy with cyclophosphamide 500 mg/m2 IV and fludarabine 30 mg/m2 IV on each of the fifth, fourth, and third day before infusion.
Precursor B-cell lymphoblastic leukemia Single IV infusion at 1 x 10^6 CAR-positive viable T cells/kg (max 1 x 10^8 cells) following lymphodepleting chemotherapy with fludarabine 25 mg/m2 IV on days -4, -3, and -2 and cyclophosphamide 900 mg/m2 IV on day -2 before infusion.
Mantle cell lymphoma 100 mg orally approximately every 12 hours until disease progression or unacceptable toxicity; swallow tablet whole with or without food (monotherapy or in combination with bendamustine and rituximab).
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma 100 mg orally approximately every 12 hours until disease progression or unacceptable toxicity (monotherapy, or in combination with obinutuzumab or venetoclax).
Contraindications
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Adverse Reactions
Most common (>=20%) - MCL CRS, fever, encephalopathy, hypotension, infection with pathogen unspecified, viral infections, fatigue, tachycardias, chills, hypoxia, tremor, cough, musculoskeletal pain, nausea, edema, headache, constipation, diarrhea, decreased appetite, dyspnea, rash, insomnia, pleural effusion, aphasia, motor dysfunction
Most common (>=20%) - ALL fever, CRS, hypotension, encephalopathy, tachycardia, nausea, chills, headache, fatigue, febrile neutropenia, diarrhea, musculoskeletal pain, hypoxia, rash, edema, tremor, infection with pathogen unspecified, constipation, decreased appetite, vomiting
Serious encephalopathy, fever, infection with pathogen unspecified, CRS, hypoxia, aphasia, renal insufficiency, pleural effusion, respiratory failure, bacterial infections, dyspnea, fatigue, arrhythmia, tachycardia, viral infections
Postmarketing infusion related reaction; T cell malignancies (identified with BCMA- or CD19-directed genetically modified autologous T cell immunotherapies)
Most common (>=30%) Upper respiratory tract infection, diarrhea, headache, musculoskeletal pain.
Serious Serious and opportunistic infections, hemorrhage, cytopenias, second primary malignancies, cardiac arrhythmias, hepatotoxicity including drug-induced liver injury.
Postmarketing Ventricular arrhythmias, drug induced liver injury.
Pharmacology
CD19-directed genetically modified autologous T cell immunotherapy; binding of anti-CD19 CAR T cells to CD19-expressing target cells activates CD28 and CD3-zeta co-stimulatory signaling cascades leading to T cell activation, proliferation, acquisition of effector functions, secretion of inflammatory cytokines and chemokines, and killing of CD19-expressing cancer and normal B cells.
Acalabrutinib is a small-molecule inhibitor of Bruton tyrosine kinase (BTK); it and its active metabolite ACP-5862 form a covalent bond with a cysteine residue in the BTK active site, inhibiting BTK enzymatic activity and downstream B-cell proliferation, trafficking, chemotaxis, and adhesion pathways required for B-cell malignancy growth.
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Most Common Insurance
Anthem BCBS
Tecartus
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (0/12)
Calquence
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Tecartus
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Calquence
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Humana
Tecartus
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Calquence
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableCancerCare: Acute Lymphoblastic Leukemia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Chronic Lymphocytic Leukemia (CLL)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.