| Medullary carcinoma of thyroid
Caprelsa vs Cometriq
Side-by-side clinical, coverage, and cost comparison for medullary carcinoma of thyroid.Deep comparison between: Caprelsa vs Cometriq with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCometriq has a higher rate of injection site reactions vs Caprelsa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Cometriq but not Caprelsa, including UnitedHealthcare
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Category
Caprelsa
Cometriq
At A Glance
Oral
Daily
Tyrosine kinase inhibitor
Oral
Daily
Multi-kinase inhibitor
Indications
- Medullary carcinoma of thyroid
- Medullary carcinoma of thyroid
Dosing
Medullary carcinoma of thyroid 300 mg orally once daily until disease progression or unacceptable toxicity; reduce to 200 mg then 100 mg for Grade 3+ toxicities or QTcF >500 ms; reduce starting dose to 200 mg in moderate renal impairment (CrCl >=30 mL/min); not recommended in moderate or severe hepatic impairment.
Medullary carcinoma of thyroid 140 mg orally once daily without food until disease progression or unacceptable toxicity; patients should not eat for at least 2 hours before and at least 1 hour after taking COMETRIQ.
Contraindications
- Congenital long QT syndrome
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Adverse Reactions
Most common (>20%) Diarrhea/colitis, rash, acneiform dermatitis, hypertension, nausea, headache, upper respiratory tract infection, decreased appetite, abdominal pain, fatigue
Serious QT prolongation and Torsades de pointes, severe skin reactions, interstitial lung disease, ischemic cerebrovascular events, hemorrhage, heart failure, hypothyroidism, hypertension, reversible posterior leukoencephalopathy syndrome, renal failure, embryo-fetal toxicity, osteonecrosis
Postmarketing Arterial aneurysms/dissections/rupture, osteonecrosis, impaired wound healing
Most common (>=25%) Diarrhea, stomatitis, palmar-plantar erythrodysesthesia, decreased weight, decreased appetite, nausea, fatigue, oral pain, hair color changes, dysgeusia, hypertension, abdominal pain, constipation
Serious Perforations and fistula, hemorrhage, thromboembolic events, impaired wound healing, hypertension and hypertensive crisis, osteonecrosis of the jaw, proteinuria, reversible posterior leukoencephalopathy syndrome, hypocalcemia
Postmarketing Supratherapeutic INR and epistaxis (with warfarin), extremity pain, arterial aneurysms, dissections, and rupture
Pharmacology
Vandetanib is a multi-targeted tyrosine kinase inhibitor that blocks the activity of EGFR and VEGFR families, RET, BRK, TIE2, and members of the EPH receptor and Src kinase families, thereby inhibiting tumor cell proliferation, angiogenesis, tumor vessel permeability, and metastasis.
Cabozantinib is a kinase inhibitor that inhibits the tyrosine kinase activity of RET, MET, VEGFR-1, -2, and -3, KIT, TRKB, FLT-3, AXL, ROS1, TYRO3, MER, and TIE-2, which are involved in oncogenesis, metastasis, tumor angiogenesis, drug resistance, and maintenance of the tumor microenvironment.
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Most Common Insurance
Anthem BCBS
Caprelsa
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (10/12) · Qty limit (11/12)
Cometriq
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Caprelsa
- Covered on 4 commercial plans
- PA (8/8) · Step Therapy (4/8) · Qty limit (2/8)
Cometriq
- Covered on 4 commercial plans
- PA (8/8) · Step Therapy (5/8) · Qty limit (3/8)
Humana
Caprelsa
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Cometriq
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$50/momo
Caprelsa Co Pay ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Renal Cell Carcinoma (RCC): Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.