| Medullary carcinoma of thyroid
Retevmo vs Cometriq
Side-by-side clinical, coverage, and cost comparison for medullary carcinoma of thyroid.Deep comparison between: Retevmo vs Cometriq with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCometriq has a higher rate of injection site reactions vs Retevmo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Cometriq but not Retevmo, including UnitedHealthcare
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Category
Retevmo
Cometriq
At A Glance
Oral
Twice daily
RET kinase inhibitor
Oral
Daily
Multi-kinase inhibitor
Indications
- Non-Small Cell Lung Carcinoma
- Medullary carcinoma of thyroid
- Thyroid carcinoma
- Medullary carcinoma of thyroid
Dosing
Non-Small Cell Lung Carcinoma, Medullary carcinoma of thyroid, Thyroid carcinoma Adults and adolescents >= 12 years: 120 mg orally twice daily (< 50 kg) or 160 mg orally twice daily (>= 50 kg); pediatric patients 2 to < 12 years: 40 mg three times daily to 160 mg twice daily orally based on body surface area; administered until disease progression or unacceptable toxicity.
Medullary carcinoma of thyroid 140 mg orally once daily without food until disease progression or unacceptable toxicity; patients should not eat for at least 2 hours before and at least 1 hour after taking COMETRIQ.
Contraindications
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Adverse Reactions
Most common (>=25%) edema, diarrhea, fatigue, dry mouth, hypertension, abdominal pain, constipation, rash, nausea, headache
Serious hepatotoxicity, interstitial lung disease/pneumonitis, hypertension, QT interval prolongation, hemorrhagic events, hypersensitivity, tumor lysis syndrome, impaired wound healing, hypothyroidism, slipped capital femoral epiphysis in adolescents
Postmarketing Stevens-Johnson Syndrome
Most common (>=25%) Diarrhea, stomatitis, palmar-plantar erythrodysesthesia, decreased weight, decreased appetite, nausea, fatigue, oral pain, hair color changes, dysgeusia, hypertension, abdominal pain, constipation
Serious Perforations and fistula, hemorrhage, thromboembolic events, impaired wound healing, hypertension and hypertensive crisis, osteonecrosis of the jaw, proteinuria, reversible posterior leukoencephalopathy syndrome, hypocalcemia
Postmarketing Supratherapeutic INR and epistaxis (with warfarin), extremity pain, arterial aneurysms, dissections, and rupture
Pharmacology
Selpercatinib is a kinase inhibitor that selectively inhibits wild-type RET and multiple mutated RET isoforms (including gene fusions and activating point mutations) as well as VEGFR1 and VEGFR3, and at clinically achievable concentrations also inhibits FGFR1, 2, and 3, blocking constitutive RET signaling that acts as an oncogenic driver promoting tumor cell proliferation.
Cabozantinib is a kinase inhibitor that inhibits the tyrosine kinase activity of RET, MET, VEGFR-1, -2, and -3, KIT, TRKB, FLT-3, AXL, ROS1, TYRO3, MER, and TIE-2, which are involved in oncogenesis, metastasis, tumor angiogenesis, drug resistance, and maintenance of the tumor microenvironment.
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Most Common Insurance
Anthem BCBS
No coverage data available for Retevmo.
Cometriq
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Retevmo
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Cometriq
- Covered on 4 commercial plans
- PA (8/8) · Step Therapy (5/8) · Qty limit (3/8)
Humana
Retevmo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Cometriq
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Retevmo.
Cost estimate not availableAssistance Fund: Renal Cell Carcinoma (RCC): Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.