| Muscular Dystrophy, Duchenne
Emflaza vs Exondys 51
Side-by-side clinical, coverage, and cost comparison for muscular dystrophy, duchenne.Deep comparison between: Emflaza vs Exondys 51 with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsExondys 51 has a higher rate of injection site reactions vs Emflaza based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Exondys 51 but not Emflaza, including UnitedHealthcare
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Category
Emflaza
Exondys 51
At A Glance
Oral
Once daily
Corticosteroid
IV infusion
Once weekly
Antisense oligonucleotide (exon 51 skipper)
Indications
- Muscular Dystrophy, Duchenne
- Muscular Dystrophy, Duchenne
Dosing
Muscular Dystrophy, Duchenne 0.9 mg/kg/day once daily orally (tablets or suspension); reduce to one third of recommended dosage when used with moderate or strong CYP3A4 inhibitors; avoid use with moderate or strong CYP3A4 inducers.
Muscular Dystrophy, Duchenne 30 mg/kg once weekly as a 35 to 60 minute IV infusion via an in-line 0.2 micron filter.
Contraindications
- Known hypersensitivity to deflazacort or any of the inactive ingredients
—
Adverse Reactions
Most common (>=5%) Cushingoid appearance, weight increased, increased appetite, upper respiratory tract infection, cough, pollakiuria, nasopharyngitis, hirsutism, central obesity, erythema, irritability, rhinorrhea, abdominal discomfort
Serious Alterations in endocrine function, immunosuppression and increased infection risk, cardiovascular/renal alterations, gastrointestinal perforation, behavioral and mood disturbances, bone effects, ophthalmic effects, serious skin rashes, growth and development effects, myopathy, Kaposi's sarcoma, thromboembolic events, anaphylaxis
Postmarketing Leukocytosis, heart failure, chorioretinopathy, corneal or scleral thinning, acute pancreatitis, peptic ulceration, edema, hypersensitivity including anaphylaxis, avascular necrosis, vertebral and long bone fractures, toxic epidermal necrolysis, thromboembolism, suicidal thoughts
Most common (>=35%) balance disorder, vomiting
Postmarketing bronchospasm, cyanosis of the lips, malaise, pyrexia, flushing, protein urine present, dehydration
Pharmacology
Deflazacort is a corticosteroid prodrug whose active metabolite, 21-desDFZ, acts through the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects; the precise mechanism of therapeutic benefit in Duchenne muscular dystrophy is unknown.
Eteplirsen is an antisense phosphorodiamidate morpholino oligomer that binds to exon 51 of dystrophin pre-mRNA, causing exon skipping during mRNA processing to allow production of an internally truncated dystrophin protein in patients with DMD mutations amenable to exon 51 skipping.
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Most Common Insurance
Anthem BCBS
Emflaza
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (0/12)
Exondys 51
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
UnitedHealthcare
Emflaza
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (1/8) · Qty limit (0/8)
Exondys 51
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Emflaza
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (1/3)
Exondys 51
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.