| Muscular Dystrophy, Duchenne
Exondys 51 vs Emflaza
Side-by-side clinical, coverage, and cost comparison for muscular dystrophy, duchenne.Deep comparison between: Exondys 51 vs Emflaza with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsEmflaza has a higher rate of injection site reactions vs Exondys 51 based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Emflaza but not Exondys 51, including UnitedHealthcare
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Category
Exondys 51
Emflaza
At A Glance
IV infusion
Once weekly
Antisense oligonucleotide (exon 51 skipper)
Oral
Once daily
Corticosteroid
Indications
- Muscular Dystrophy, Duchenne
- Muscular Dystrophy, Duchenne
Dosing
Muscular Dystrophy, Duchenne 30 mg/kg once weekly as a 35 to 60 minute IV infusion via an in-line 0.2 micron filter.
Muscular Dystrophy, Duchenne 0.9 mg/kg/day once daily orally (tablets or suspension); reduce to one third of recommended dosage when used with moderate or strong CYP3A4 inhibitors; avoid use with moderate or strong CYP3A4 inducers.
Contraindications
—
- Known hypersensitivity to deflazacort or any of the inactive ingredients
Adverse Reactions
Most common (>=35%) balance disorder, vomiting
Postmarketing bronchospasm, cyanosis of the lips, malaise, pyrexia, flushing, protein urine present, dehydration
Most common (>=5%) Cushingoid appearance, weight increased, increased appetite, upper respiratory tract infection, cough, pollakiuria, nasopharyngitis, hirsutism, central obesity, erythema, irritability, rhinorrhea, abdominal discomfort
Serious Alterations in endocrine function, immunosuppression and increased infection risk, cardiovascular/renal alterations, gastrointestinal perforation, behavioral and mood disturbances, bone effects, ophthalmic effects, serious skin rashes, growth and development effects, myopathy, Kaposi's sarcoma, thromboembolic events, anaphylaxis
Postmarketing Leukocytosis, heart failure, chorioretinopathy, corneal or scleral thinning, acute pancreatitis, peptic ulceration, edema, hypersensitivity including anaphylaxis, avascular necrosis, vertebral and long bone fractures, toxic epidermal necrolysis, thromboembolism, suicidal thoughts
Pharmacology
Eteplirsen is an antisense phosphorodiamidate morpholino oligomer that binds to exon 51 of dystrophin pre-mRNA, causing exon skipping during mRNA processing to allow production of an internally truncated dystrophin protein in patients with DMD mutations amenable to exon 51 skipping.
Deflazacort is a corticosteroid prodrug whose active metabolite, 21-desDFZ, acts through the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects; the precise mechanism of therapeutic benefit in Duchenne muscular dystrophy is unknown.
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Most Common Insurance
Anthem BCBS
Exondys 51
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Emflaza
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (0/12)
UnitedHealthcare
Exondys 51
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Emflaza
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Exondys 51
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Emflaza
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.