| Muscular Dystrophy, Duchenne
Viltepso vs Emflaza
Side-by-side clinical, coverage, and cost comparison for muscular dystrophy, duchenne.Deep comparison between: Viltepso vs Emflaza with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsEmflaza has a higher rate of injection site reactions vs Viltepso based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Emflaza but not Viltepso, including UnitedHealthcare
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Category
Viltepso
Emflaza
At A Glance
IV infusion
Once weekly
Antisense oligonucleotide (PMO)
Oral
Once daily
Corticosteroid
Indications
- Muscular Dystrophy, Duchenne
- Muscular Dystrophy, Duchenne
Dosing
Muscular Dystrophy, Duchenne 80 mg/kg once weekly as a 60-minute IV infusion; serum cystatin C, urine dipstick, and urine protein-to-creatinine ratio should be measured before starting.
Muscular Dystrophy, Duchenne 0.9 mg/kg/day once daily orally (tablets or suspension); reduce to one third of recommended dosage when used with moderate or strong CYP3A4 inhibitors; avoid use with moderate or strong CYP3A4 inducers.
Contraindications
—
- Known hypersensitivity to deflazacort or any of the inactive ingredients
Adverse Reactions
Most common (>=15%) Upper respiratory tract infection, injection site reaction, cough, pyrexia
Common (>=10%) Contusion, arthralgia, diarrhea, vomiting, abdominal pain, ejection fraction decreased, urticaria
Most common (>=5%) Cushingoid appearance, weight increased, increased appetite, upper respiratory tract infection, cough, pollakiuria, nasopharyngitis, hirsutism, central obesity, erythema, irritability, rhinorrhea, abdominal discomfort
Serious Alterations in endocrine function, immunosuppression and increased infection risk, cardiovascular/renal alterations, gastrointestinal perforation, behavioral and mood disturbances, bone effects, ophthalmic effects, serious skin rashes, growth and development effects, myopathy, Kaposi's sarcoma, thromboembolic events, anaphylaxis
Postmarketing Leukocytosis, heart failure, chorioretinopathy, corneal or scleral thinning, acute pancreatitis, peptic ulceration, edema, hypersensitivity including anaphylaxis, avascular necrosis, vertebral and long bone fractures, toxic epidermal necrolysis, thromboembolism, suicidal thoughts
Pharmacology
Viltolarsen is an antisense oligonucleotide (phosphorodiamidate morpholino oligomer subclass) that binds to exon 53 of dystrophin pre-mRNA, causing exon 53 skipping during mRNA processing and enabling production of an internally truncated dystrophin protein in patients with DMD gene mutations amenable to exon 53 skipping.
Deflazacort is a corticosteroid prodrug whose active metabolite, 21-desDFZ, acts through the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects; the precise mechanism of therapeutic benefit in Duchenne muscular dystrophy is unknown.
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Most Common Insurance
Anthem BCBS
Viltepso
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Emflaza
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (0/12)
UnitedHealthcare
Viltepso
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Emflaza
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Viltepso
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Emflaza
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.