| Muscular Dystrophy, Duchenne
Viltepso vs Vyondys 53
Side-by-side clinical, coverage, and cost comparison for muscular dystrophy, duchenne.Deep comparison between: Viltepso vs Vyondys 53 with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVyondys 53 has a higher rate of injection site reactions vs Viltepso based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vyondys 53 but not Viltepso, including UnitedHealthcare
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Category
Viltepso
Vyondys 53
At A Glance
IV infusion
Once weekly
Antisense oligonucleotide (PMO)
IV infusion
Once weekly
Exon 53 skipping antisense oligonucleotide
Indications
- Muscular Dystrophy, Duchenne
- Muscular Dystrophy, Duchenne
Dosing
Muscular Dystrophy, Duchenne 80 mg/kg once weekly as a 60-minute IV infusion; serum cystatin C, urine dipstick, and urine protein-to-creatinine ratio should be measured before starting.
Muscular Dystrophy, Duchenne 30 mg/kg IV infusion once weekly over 35 to 60 minutes via an in-line 0.2 micron filter.
Contraindications
—
- Serious hypersensitivity reaction to golodirsen or any inactive ingredient in VYONDYS 53
Adverse Reactions
Most common (>=15%) Upper respiratory tract infection, injection site reaction, cough, pyrexia
Common (>=10%) Contusion, arthralgia, diarrhea, vomiting, abdominal pain, ejection fraction decreased, urticaria
Most common (>=20%) Headache, pyrexia, fall, abdominal pain, nasopharyngitis, cough, vomiting, nausea
Serious Hypersensitivity reactions
Postmarketing Anaphylaxis
Pharmacology
Viltolarsen is an antisense oligonucleotide (phosphorodiamidate morpholino oligomer subclass) that binds to exon 53 of dystrophin pre-mRNA, causing exon 53 skipping during mRNA processing and enabling production of an internally truncated dystrophin protein in patients with DMD gene mutations amenable to exon 53 skipping.
Golodirsen is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer (PMO) subclass that binds to exon 53 of dystrophin pre-mRNA, inducing exon 53 exclusion during mRNA processing to allow production of an internally truncated dystrophin protein in patients with DMD gene mutations amenable to exon 53 skipping.
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Most Common Insurance
Anthem BCBS
Viltepso
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Vyondys 53
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
UnitedHealthcare
Viltepso
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Vyondys 53
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Viltepso
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Vyondys 53
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Duchenne Muscular Dystrophy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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ViltepsoView full Viltepso profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.