| MYELODYSPLASTIC SYNDROME

Reblozyl vs Inqovi

Side-by-side clinical, coverage, and cost comparison for myelodysplastic syndrome.

Deep comparison between: Reblozyl vs Inqovi with Prescriber.AI

AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.

Safety signalsInqovi has a higher rate of injection site reactions vs Reblozyl based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Inqovi but not Reblozyl, including UnitedHealthcare

Category

Reblozyl

Inqovi

At A Glance

RouteSC injection

FrequencyEvery 3 weeks

ClassErythroid maturation agent

RouteOral

FrequencyOnce daily, Days 1-5 of each 28-day cycle

ClassNucleoside metabolic inhibitor

Indications

beta Thalassemia
MYELODYSPLASTIC SYNDROME
Refractory anemia with ringed sideroblasts
Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis

MYELODYSPLASTIC SYNDROME
Refractory anemias
Refractory anemia with ringed sideroblasts
Refractory anaemia with excess blasts
Leukemia, Myelomonocytic, Chronic

Dosing

beta Thalassemia 1 mg/kg SC every 3 weeks; increase to max 1.25 mg/kg if no reduction in RBC transfusion burden after at least 2 consecutive doses at 1 mg/kg.

MYELODYSPLASTIC SYNDROME (ESA-naive) 1 mg/kg SC every 3 weeks; increase up to max 1.75 mg/kg to maintain hemoglobin 10 g/dL to 12 g/dL.

Refractory anemia with ringed sideroblasts, Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis (ESA-refractory or intolerant) 1 mg/kg SC every 3 weeks; increase to max 1.75 mg/kg if patient is not RBC transfusion-free.

MYELODYSPLASTIC SYNDROME, Refractory anemias, Refractory anemia with ringed sideroblasts, Refractory anaemia with excess blasts, Leukemia, Myelomonocytic, Chronic 1 tablet (35 mg decitabine and 100 mg cedazuridine) orally once daily on Days 1 through 5 of each 28-day cycle, taken on an empty stomach; minimum of 4 cycles until disease progression or unacceptable toxicity.

Contraindications

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Drug Interactions

373View drug interactions

1011View drug interactions

Adverse Reactions

Most common (>=10%) headache, bone pain, arthralgia, fatigue, cough, abdominal pain, diarrhea, dizziness, hypertension, nausea, edema peripheral, dyspnea, musculoskeletal pain

Serious thrombosis/thromboembolism, hypertension, extramedullary hematopoietic masses, cerebrovascular accident, deep vein thrombosis

Most common (>=20%) fatigue, constipation, hemorrhage, myalgia, mucositis, arthralgia, nausea, dyspnea, diarrhea, rash, dizziness, febrile neutropenia, edema, headache, cough, decreased appetite, upper respiratory tract infection, pneumonia, transaminase increased

Serious febrile neutropenia, pneumonia, sepsis

Postmarketing differentiation syndrome, interstitial lung disease, cardiomyopathy

Pharmacology

Luspatercept-aamt is a recombinant fusion protein that binds several endogenous TGF-beta superfamily ligands, thereby diminishing Smad2/3 signaling and promoting erythroid maturation by increasing late-stage erythroid precursors (normoblasts) to reduce ineffective erythropoiesis in beta-thalassemia and MDS.

Decitabine is a nucleoside metabolic inhibitor that incorporates into DNA and inhibits DNA methyltransferase, causing hypomethylation and cellular differentiation or apoptosis; cedazuridine inhibits cytidine deaminase in the gastrointestinal tract and liver to increase systemic exposure of orally administered decitabine.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Reblozyl