| Myocardial Infarction
Lipitor vs Vascepa
Side-by-side clinical, coverage, and cost comparison for myocardial infarction.Deep comparison between: Lipitor vs Vascepa with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVascepa has a higher rate of injection site reactions vs Lipitor based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vascepa but not Lipitor, including UnitedHealthcare
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Category
Lipitor
Vascepa
At A Glance
Oral
Daily
HMG-CoA reductase inhibitor (statin)
Oral
Twice daily
Omega-3 fatty acid
Indications
- Myocardial Infarction
- Cerebrovascular accident
- Stable angina
- Diabetes Mellitus, Non-Insulin-Dependent
- Congestive heart failure
- Hyperlipidemia
- Familial hypercholesterolemia - heterozygous
- Homozygous Familial Hypercholesterolemia
- Hyperlipoproteinemia Type III
- Hypertriglyceridemia
- Myocardial Infarction
- Cerebrovascular accident
- Angina, Unstable
- Hypertriglyceridemia
Dosing
Myocardial Infarction, Cerebrovascular accident, Stable angina, Diabetes Mellitus Non-Insulin-Dependent, Congestive heart failure, Hyperlipidemia, Hyperlipoproteinemia Type III, Hypertriglyceridemia 10 or 20 mg once daily starting; range 10-80 mg once daily; patients requiring LDL-C reduction >45% may start at 40 mg once daily; oral.
Familial hypercholesterolemia - heterozygous Adults: 10 or 20 mg once daily, range 10-80 mg once daily; pediatric patients aged >=10 years: 10 mg once daily starting, range 10-20 mg once daily; oral.
Homozygous Familial Hypercholesterolemia Adults: 10 or 20 mg once daily, range 10-80 mg once daily; pediatric patients aged >=10 years: 10-20 mg once daily starting, range 10-80 mg once daily; oral.
Myocardial Infarction, Cerebrovascular accident, Angina, Unstable 4 grams per day (four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food) as adjunct to maximally tolerated statin therapy.
Hypertriglyceridemia 4 grams per day (four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food) as adjunct to diet.
Contraindications
- Acute liver failure or decompensated cirrhosis
- Hypersensitivity to atorvastatin or any excipient in Lipitor
- Known hypersensitivity (e.g., anaphylactic reaction) to icosapent ethyl or any of its components
Adverse Reactions
Most common (>=2%) Nasopharyngitis, arthralgia, diarrhea, pain in extremity, urinary tract infection, dyspepsia, nausea, musculoskeletal pain, muscle spasms, myalgia, insomnia, pharyngolaryngeal pain
Serious Myopathy and rhabdomyolysis, immune-mediated necrotizing myopathy, hepatic dysfunction, increases in HbA1c and fasting serum glucose
Postmarketing Pancreatitis, fatigue, fatal and non-fatal hepatic failure, anaphylaxis, tendon rupture, rhabdomyolysis, myositis, dizziness, peripheral neuropathy, cognitive impairment, myasthenia gravis exacerbation, depression, interstitial lung disease, angioneurotic edema, bullous rashes
Most common (>=3%) musculoskeletal pain, peripheral edema, constipation, gout, atrial fibrillation
Postmarketing diarrhea, blood triglycerides increased, abdominal discomfort, pain in the extremities
Pharmacology
Lipitor is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of cholesterol; it lowers plasma LDL cholesterol and lipoprotein levels by inhibiting hepatic cholesterol synthesis and upregulating LDL receptor expression on hepatic cell surfaces.
Icosapent ethyl (EPA ethyl ester) reduces hepatic VLDL-TG synthesis and/or secretion and enhances TG clearance from circulating VLDL particles, with multi-factorial mechanisms likely contributing to cardiovascular risk reduction.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Lipitor
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (5/12) · Qty limit (1/12)
Vascepa
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (3/12) · Qty limit (9/12)
UnitedHealthcare
Lipitor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Vascepa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Lipitor
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (1/3)
Vascepa
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Lipitor.
No savings programs available for Vascepa.
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LipitorView full Lipitor profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.