| Myocardial Infarction
Vascepa vs Brilinta
Side-by-side clinical, coverage, and cost comparison for myocardial infarction.Deep comparison between: Vascepa vs Brilinta with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsBrilinta has a higher rate of injection site reactions vs Vascepa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Brilinta but not Vascepa, including UnitedHealthcare
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Category
Vascepa
Brilinta
At A Glance
Oral
Twice daily
Omega-3 fatty acid
Oral
Twice daily
P2Y12 platelet inhibitor
Indications
- Myocardial Infarction
- Cerebrovascular accident
- Angina, Unstable
- Hypertriglyceridemia
- Acute Coronary Syndrome
- Myocardial Infarction
- Coronary Artery Disease
- Acute Ischemic Stroke
- Transient Ischemic Attack
- Stent thrombosis
Dosing
Myocardial Infarction, Cerebrovascular accident, Angina, Unstable 4 grams per day (four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food) as adjunct to maximally tolerated statin therapy.
Hypertriglyceridemia 4 grams per day (four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food) as adjunct to diet.
Acute Coronary Syndrome, Myocardial Infarction, Stent thrombosis 180 mg oral loading dose, then 90 mg twice daily for the first year; after one year, 60 mg twice daily; use with aspirin 75-100 mg daily.
Coronary Artery Disease 60 mg twice daily; use with aspirin 75-100 mg daily.
Acute Ischemic Stroke, Transient Ischemic Attack 180 mg loading dose, then 90 mg twice daily for up to 30 days; use with aspirin 300-325 mg loading dose and 75-100 mg daily maintenance.
Contraindications
- Known hypersensitivity (e.g., anaphylactic reaction) to icosapent ethyl or any of its components
- History of intracranial hemorrhage
- Active pathological bleeding (e.g., peptic ulcer or intracranial hemorrhage)
- Hypersensitivity (e.g., angioedema) to ticagrelor or any component of the product
Adverse Reactions
Most common (>=3%) musculoskeletal pain, peripheral edema, constipation, gout, atrial fibrillation
Postmarketing diarrhea, blood triglycerides increased, abdominal discomfort, pain in the extremities
Most common (>=4%) Dyspnea, dizziness, nausea, bleeding
Serious Major bleeding, fatal/life-threatening bleeding, intracranial hemorrhage, bradycardia, ventricular pauses
Postmarketing Thrombotic Thrombocytopenic Purpura, hypersensitivity reactions including angioedema, central sleep apnea, Cheyne-Stokes respiration, rash
Pharmacology
Icosapent ethyl (EPA ethyl ester) reduces hepatic VLDL-TG synthesis and/or secretion and enhances TG clearance from circulating VLDL particles, with multi-factorial mechanisms likely contributing to cardiovascular risk reduction.
P2Y12 platelet inhibitor; ticagrelor and its major metabolite reversibly interact with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation, with ticagrelor and its active metabolite being approximately equipotent.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Vascepa
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (3/12) · Qty limit (9/12)
Brilinta
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (3/12) · Qty limit (9/12)
UnitedHealthcare
Vascepa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Brilinta
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (3/8)
Humana
Vascepa
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Brilinta
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Vascepa.
No savings programs available for Brilinta.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.