| Myocardial Infarction
Vascepa vs Kerendia
Side-by-side clinical, coverage, and cost comparison for myocardial infarction.Deep comparison between: Vascepa vs Kerendia with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsKerendia has a higher rate of injection site reactions vs Vascepa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Kerendia but not Vascepa, including UnitedHealthcare
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Category
Vascepa
Kerendia
At A Glance
Oral
Twice daily
Omega-3 fatty acid
Oral
Once daily
Mineralocorticoid receptor antagonist
Indications
- Myocardial Infarction
- Cerebrovascular accident
- Angina, Unstable
- Hypertriglyceridemia
- Chronic Kidney Diseases
- Diabetes Mellitus, Non-Insulin-Dependent
- Heart failure
- Chronic kidney disease stage 5
- Myocardial Infarction
Dosing
Myocardial Infarction, Cerebrovascular accident, Angina, Unstable 4 grams per day (four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food) as adjunct to maximally tolerated statin therapy.
Hypertriglyceridemia 4 grams per day (four 0.5 gram capsules twice daily with food or two 1 gram capsules twice daily with food) as adjunct to diet.
Chronic Kidney Diseases, Diabetes Mellitus, Non-Insulin-Dependent Starting dose 10 mg or 20 mg orally once daily based on eGFR and serum potassium; target dose 20 mg once daily, adjusted after 4 weeks based on serum potassium levels.
Heart failure Starting dose 10 mg or 20 mg orally once daily based on eGFR and serum potassium; target dose 20 mg or 40 mg once daily based on eGFR at initiation, adjusted after 4 weeks.
Contraindications
- Known hypersensitivity (e.g., anaphylactic reaction) to icosapent ethyl or any of its components
- Hypersensitivity to any component of Kerendia
- Concomitant treatment with strong CYP3A4 inhibitors
- Adrenal insufficiency
Adverse Reactions
Most common (>=3%) musculoskeletal pain, peripheral edema, constipation, gout, atrial fibrillation
Postmarketing diarrhea, blood triglycerides increased, abdominal discomfort, pain in the extremities
Most common (>=10%) hyperkalemia
Serious hyperkalemia requiring hospitalization, renal impairment, acute kidney injury, renal failure
Postmarketing angioedema, rash, urticaria
Pharmacology
Icosapent ethyl (EPA ethyl ester) reduces hepatic VLDL-TG synthesis and/or secretion and enhances TG clearance from circulating VLDL particles, with multi-factorial mechanisms likely contributing to cardiovascular risk reduction.
Finerenone is a nonsteroidal, selective mineralocorticoid receptor (MR) antagonist that blocks MR-mediated sodium reabsorption and MR overactivation in epithelial (kidney) and nonepithelial (heart, blood vessels) tissues; it has high potency and selectivity for the MR with no relevant affinity for androgen, progesterone, estrogen, or glucocorticoid receptors.
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Most Common Insurance
Anthem BCBS
Vascepa
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (3/12) · Qty limit (9/12)
Kerendia
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (11/12)
UnitedHealthcare
Vascepa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Kerendia
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (6/8)
Humana
Vascepa
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Kerendia
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Vascepa.
$0/fillfill
Bayer US Patient Assistance Foundation - KerendiaCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.