| Nephrotic Syndrome

Flexbumin 25% vs Purified Cortrophin Gel

Side-by-side clinical, coverage, and cost comparison for nephrotic syndrome.

Deep comparison between: Flexbumin vs Purified Cortrophin Gel with Prescriber.AI

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Safety signalsPurified Cortrophin Gel has a higher rate of injection site reactions vs Flexbumin based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Purified Cortrophin Gel but not Flexbumin, including UnitedHealthcare

Category

Flexbumin

Purified Cortrophin Gel

At A Glance

RouteIV infusion

ClassHuman albumin / plasma volume expander

RouteSC/IM injection

ClassCorticotropin (ACTH)

Indications

Hypoalbuminemia
Respiratory Distress Syndrome, Adult
Nephrotic Syndrome
Erythroblastosis, Fetal

Arthritis, Psoriatic
Rheumatoid Arthritis
Ankylosing spondylitis
Primary gout
Lupus Erythematosus, Systemic
Polymyositis
Stevens-Johnson Syndrome
Psoriasis
Dermatitis, Atopic
Serum Sickness
Allergic Conjunctivitis
Keratitis
Iritis
Iridocyclitis
Uveitis
Optic Neuritis
Chorioretinitis
Sarcoidosis
Nephrotic Syndrome
Multiple Sclerosis

Dosing

Hypovolemic Shock Infants and young children: 2.5 to 5 mL per kg body weight IV; older children and adults: initial dose 100 to 200 mL IV, repeated after 15 to 30 minutes if response is inadequate. Do not exceed 1 mL/min in patients with normal blood volume.

Hypoalbuminemia Calculate body albumin compartment to be 80 to 100 mL per kg body weight; do not exceed a daily dose of 2 g of albumin per kg of body weight, administered IV.

Burns Dose determined by patient's condition and response to treatment after the first 24 hours, administered IV.

Erythroblastosis, Fetal 1 g per kilogram body weight IV prior to or during exchange transfusion.

Arthritis, Psoriatic, Rheumatoid Arthritis, Ankylosing spondylitis, Primary gout, Lupus Erythematosus, Systemic, Polymyositis, Stevens-Johnson Syndrome, Psoriasis, Dermatitis, Atopic, Serum Sickness, Allergic Conjunctivitis, Keratitis, Iritis, Iridocyclitis, Uveitis, Optic Neuritis, Chorioretinitis, Sarcoidosis, Nephrotic Syndrome Dose individualized based on disease severity, plasma and urine corticosteroid levels, and patient response; administer SC or IM; verify adrenal responsiveness prior to treatment (up to 80 units as a single injection); chronic doses above 40 units daily associated with uncontrollable adverse effects.

Multiple Sclerosis 80-120 units daily SC or IM for 2-3 weeks for acute exacerbations.

Contraindications

History of hypersensitivity reaction to albumin preparations or to any excipient (N-acetyltryptophan and sodium caprylate)
Severe anemia or cardiac failure with normal or increased intravascular volume

Intravenous administration
Scleroderma
Osteoporosis
Systemic fungal infections
Ocular herpes simplex
Recent surgery
History of or presence of a peptic ulcer
Congestive heart failure
Hypertension
Sensitivity to proteins derived from porcine sources
Primary adrenocortical insufficiency
Adrenocortical hyperfunction

Drug Interactions

2410View drug interactions

648View drug interactions

Adverse Reactions

Serious Hypersensitivity reaction, anaphylactic reaction, pulmonary edema

Postmarketing Anaphylactic shock, anaphylactic reaction, hypersensitivity/allergic reactions, headache, dysgeusia, myocardial infarction, atrial fibrillation, tachycardia, hypotension, flushing, pulmonary edema, dyspnea, vomiting, nausea, urticaria, rash, pruritus, pyrexia, chills

Fluid and Electrolyte Sodium retention, hypokalemic alkalosis, fluid retention, calcium loss, potassium loss

Musculoskeletal Muscle weakness, loss of muscle mass, steroid myopathy, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones

Gastrointestinal Peptic ulcer with possible perforation and hemorrhage, abdominal distention, ulcerative esophagitis, pancreatitis

Dermatologic Injection site reactions, impaired wound healing, increased sweating, thin fragile skin, suppression of skin test reactions, petechiae and ecchymoses, acne, hyperpigmentation, facial erythema

Cardiovascular Hypertension, congestive heart failure, necrotizing angiitis

Neurological Convulsions, increased intracranial pressure with papilledema, headache, vertigo

Endocrine Menstrual irregularities, Cushingoid state, suppression of growth in children, secondary adrenocortical and pituitary insufficiency, decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic agents, hirsutism

Ophthalmic Posterior subcapsular cataracts, increased intraocular pressure, glaucoma with possible damage to optic nerve, exophthalmos

Metabolic Negative nitrogen balance due to protein catabolism

Allergic Dizziness, nausea and vomiting, skin reactions, anaphylaxis (anaphylactic shock, urticaria, respiratory compromise, edema)

Miscellaneous Weight gain, abscess, development of antibodies and loss of stimulatory effect

Pharmacology

Human albumin accounts for 70 to 80% of the colloid osmotic pressure of normal plasma and serves as a transport protein; administered as a 25% IV solution, it draws approximately 3.5 times its volume of additional fluid into the circulation within 15 minutes, expanding blood volume.

Purified Cortrophin Gel is an anterior pituitary hormone (corticotropin/ACTH) that stimulates the functioning adrenal cortex to produce and secrete adrenocortical hormones; it is formulated as a porcine-derived purified ACTH in a sterile gelatin solution for prolonged activity.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Flexbumin