| Ocular Hypertension
Alphagan P vs Combigan
Side-by-side clinical, coverage, and cost comparison for ocular hypertension.Deep comparison between: Alphagan P vs Combigan with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCombigan has a higher rate of injection site reactions vs Alphagan P based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Combigan but not Alphagan P, including UnitedHealthcare
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Category
Alphagan P
Combigan
At A Glance
Ophthalmic
Three times daily
Alpha-2 adrenergic receptor agonist
Topical (ophthalmic)
Twice daily
Alpha-2 agonist / beta-blocker
Indications
- Glaucoma, Open-Angle
- Ocular Hypertension
- Glaucoma
- Ocular Hypertension
Dosing
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) three times daily, approximately 8 hours apart; if used with other topical ophthalmic products, instill at least 5 minutes apart.
Glaucoma, Ocular Hypertension One drop in the affected eye(s) twice daily approximately 12 hours apart; if using multiple topical ophthalmic products, instill at least 5 minutes apart.
Contraindications
- Neonates and infants (pediatric patients younger than 2 years old)
- Previous hypersensitivity reaction to any component of ALPHAGAN P
- Bronchial asthma, history of bronchial asthma, or severe chronic obstructive pulmonary disease
- Sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, or cardiogenic shock
- Neonates and infants (pediatric patients younger than 2 years old)
- Hypersensitivity to any component of this product
Adverse Reactions
Most common (>=10%) Allergic conjunctivitis, conjunctival hyperemia, eye pruritus
Serious Potentiation of vascular insufficiency, severe cardiovascular disease
Postmarketing Bradycardia, depression, hypersensitivity, iritis, keratoconjunctivitis sicca, miosis, nausea, skin reactions, syncope, tachycardia
Most common (5%-15%) allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, stinging
Serious hypersensitivity reactions, severe respiratory or cardiac reactions, cardiac failure, potentiation of vascular insufficiency, increased reactivity to allergens, potentiation of muscle weakness, masking of hypoglycemia, masking of thyrotoxicosis, ocular hypersensitivity
Postmarketing bradycardia, eyelid erythema, hypersensitivity, iritis, keratoconjunctivitis sicca, miosis, nausea, skin reactions, syncope, tachycardia
Pharmacology
Brimonidine tartrate is a relatively selective alpha-2 adrenergic receptor agonist that lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow, with a peak ocular hypotensive effect at approximately 2 hours post-dosing.
COMBIGAN combines brimonidine tartrate, a relatively selective alpha-2 adrenergic receptor agonist that reduces aqueous humor production and increases uveoscleral outflow, with timolol maleate, a non-selective beta-1 and beta-2 adrenergic receptor inhibitor, to lower elevated intraocular pressure.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Alphagan P
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Combigan
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Alphagan P
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Combigan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Humana
Alphagan P
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (3/3) · Qty limit (0/3)
Combigan
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Alphagan P.
No savings programs available for Combigan.
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Alphagan PView full Alphagan P profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.