| Ocular Hypertension
Alphagan P vs Lumigan
Side-by-side clinical, coverage, and cost comparison for ocular hypertension.Deep comparison between: Alphagan P vs Lumigan with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLumigan has a higher rate of injection site reactions vs Alphagan P based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Lumigan but not Alphagan P, including UnitedHealthcare
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Category
Alphagan P
Lumigan
At A Glance
Ophthalmic
Three times daily
Alpha-2 adrenergic receptor agonist
Ophthalmic
Once daily
Prostaglandin analog
Indications
- Glaucoma, Open-Angle
- Ocular Hypertension
- Glaucoma, Open-Angle
- Ocular Hypertension
Dosing
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) three times daily, approximately 8 hours apart; if used with other topical ophthalmic products, instill at least 5 minutes apart.
Glaucoma, Open-Angle; Ocular Hypertension One drop in the affected eye(s) once daily in the evening; if used concomitantly with other topical ophthalmic drugs, administer at least 5 minutes apart.
Contraindications
- Neonates and infants (pediatric patients younger than 2 years old)
- Previous hypersensitivity reaction to any component of ALPHAGAN P
- Hypersensitivity to bimatoprost or any excipient
Adverse Reactions
Most common (>=10%) Allergic conjunctivitis, conjunctival hyperemia, eye pruritus
Serious Potentiation of vascular insufficiency, severe cardiovascular disease
Postmarketing Bradycardia, depression, hypersensitivity, iritis, keratoconjunctivitis sicca, miosis, nausea, skin reactions, syncope, tachycardia
Most common (>=1%) Conjunctival hyperemia, conjunctival edema, conjunctival hemorrhage, eye irritation, eye pain, eye pruritus, erythema of eyelid, eyelid pruritus, growth of eyelashes, hypertrichosis, instillation site irritation, punctate keratitis, skin hyperpigmentation, blurred vision, reduced visual acuity
Postmarketing Asthma-like symptoms, dizziness, dry eye, dyspnea, eye discharge, eye edema, foreign body sensation, headache, hypersensitivity, hypertension, increased lacrimation, periorbital and lid changes, photophobia
Pharmacology
Brimonidine tartrate is a relatively selective alpha-2 adrenergic receptor agonist that lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow, with a peak ocular hypotensive effect at approximately 2 hours post-dosing.
Bimatoprost is a prostaglandin analog that lowers intraocular pressure by increasing aqueous humor outflow through both the trabecular meshwork and uveoscleral routes, selectively mimicking naturally occurring prostamides.
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Most Common Insurance
Anthem BCBS
Alphagan P
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Lumigan
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (1/12) · Qty limit (9/12)
UnitedHealthcare
Alphagan P
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Lumigan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Alphagan P
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (3/3) · Qty limit (0/3)
Lumigan
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Alphagan P.
No savings programs available for Lumigan.
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Alphagan PView full Alphagan P profile
LumiganView full Lumigan profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.