| Ocular Hypertension
Combigan vs Durysta
Side-by-side clinical, coverage, and cost comparison for ocular hypertension.Deep comparison between: Combigan vs Durysta with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsDurysta has a higher rate of injection site reactions vs Combigan based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Durysta but not Combigan, including UnitedHealthcare
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Category
Combigan
Durysta
At A Glance
Topical (ophthalmic)
Twice daily
Alpha-2 agonist / beta-blocker
Intracameral implant
Single dose
Prostaglandin analog
Indications
- Glaucoma
- Ocular Hypertension
- Glaucoma, Open-Angle
- Ocular Hypertension
Dosing
Glaucoma, Ocular Hypertension One drop in the affected eye(s) twice daily approximately 12 hours apart; if using multiple topical ophthalmic products, instill at least 5 minutes apart.
Glaucoma, Open-Angle, Ocular Hypertension Single biodegradable intracameral implant (10 mcg bimatoprost) administered once into the anterior chamber under aseptic conditions; do not readminister to a previously treated eye.
Contraindications
- Bronchial asthma, history of bronchial asthma, or severe chronic obstructive pulmonary disease
- Sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, or cardiogenic shock
- Neonates and infants (pediatric patients younger than 2 years old)
- Hypersensitivity to any component of this product
- Active or suspected ocular or periocular infections
- Corneal endothelial cell dystrophy (e.g., Fuchs' Dystrophy)
- Prior corneal transplantation or endothelial cell transplants (e.g., DSAEK)
- Absent or ruptured posterior lens capsule (risk of implant migration into the posterior segment)
- Hypersensitivity to bimatoprost or any other component of the product
Adverse Reactions
Most common (5%-15%) allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, stinging
Serious hypersensitivity reactions, severe respiratory or cardiac reactions, cardiac failure, potentiation of vascular insufficiency, increased reactivity to allergens, potentiation of muscle weakness, masking of hypoglycemia, masking of thyrotoxicosis, ocular hypersensitivity
Postmarketing bradycardia, eyelid erythema, hypersensitivity, iritis, keratoconjunctivitis sicca, miosis, nausea, skin reactions, syncope, tachycardia
Most common (>=5%) Conjunctival hyperemia (27%), foreign body sensation, eye pain, photophobia, conjunctival hemorrhage, dry eye, eye irritation, increased IOP, corneal endothelial cell loss, blurred vision, iritis, headache
Serious Implant migration, hypersensitivity, corneal adverse reactions, macular edema, intraocular inflammation, pigmentation, endophthalmitis
Postmarketing Endophthalmitis
Pharmacology
COMBIGAN combines brimonidine tartrate, a relatively selective alpha-2 adrenergic receptor agonist that reduces aqueous humor production and increases uveoscleral outflow, with timolol maleate, a non-selective beta-1 and beta-2 adrenergic receptor inhibitor, to lower elevated intraocular pressure.
Bimatoprost is a prostaglandin analog with ocular hypotensive activity that lowers IOP by increasing aqueous humor outflow through both the trabecular meshwork (conventional) and uveoscleral (unconventional) routes.
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Most Common Insurance
Anthem BCBS
Combigan
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Durysta
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Combigan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Durysta
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Combigan
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Durysta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Combigan.
$0/fillfill
Durysta CoPay Assistance ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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CombiganView full Combigan profile
DurystaView full Durysta profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.