| Ocular Hypertension
Combigan vs Xalatan
Side-by-side clinical, coverage, and cost comparison for ocular hypertension.Deep comparison between: Combigan vs Xalatan with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXalatan has a higher rate of injection site reactions vs Combigan based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xalatan but not Combigan, including UnitedHealthcare
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Category
Combigan
Xalatan
At A Glance
Topical (ophthalmic)
Twice daily
Alpha-2 agonist / beta-blocker
Ophthalmic
Once daily
Prostaglandin F2-alpha analogue
Indications
- Glaucoma
- Ocular Hypertension
- Glaucoma, Open-Angle
- Ocular Hypertension
Dosing
Glaucoma, Ocular Hypertension One drop in the affected eye(s) twice daily approximately 12 hours apart; if using multiple topical ophthalmic products, instill at least 5 minutes apart.
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) once daily in the evening; do not exceed once daily dosing.
Contraindications
- Bronchial asthma, history of bronchial asthma, or severe chronic obstructive pulmonary disease
- Sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, or cardiogenic shock
- Neonates and infants (pediatric patients younger than 2 years old)
- Hypersensitivity to any component of this product
- Known hypersensitivity to latanoprost, benzalkonium chloride, or any other ingredients in this product
Adverse Reactions
Most common (5%-15%) allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, stinging
Serious hypersensitivity reactions, severe respiratory or cardiac reactions, cardiac failure, potentiation of vascular insufficiency, increased reactivity to allergens, potentiation of muscle weakness, masking of hypoglycemia, masking of thyrotoxicosis, ocular hypersensitivity
Postmarketing bradycardia, eyelid erythema, hypersensitivity, iritis, keratoconjunctivitis sicca, miosis, nausea, skin reactions, syncope, tachycardia
Most common (5-15%) Foreign body sensation, punctate keratitis, stinging, conjunctival hyperemia, blurred vision, itching, burning, increased pigmentation of the iris
Serious Iris pigmentation changes, eyelid skin darkening, eyelash changes, intraocular inflammation (iritis/uveitis), macular edema including cystoid macular edema
Postmarketing Dizziness, headache, toxic epidermal necrolysis, keratitis, corneal edema and erosions, trichiasis, iris cyst, conjunctivitis, pseudopemphigoid of the ocular conjunctiva, asthma, dyspnea, nausea, vomiting, pruritis, herpes keratitis, angina, palpitations, chest pain
Pharmacology
COMBIGAN combines brimonidine tartrate, a relatively selective alpha-2 adrenergic receptor agonist that reduces aqueous humor production and increases uveoscleral outflow, with timolol maleate, a non-selective beta-1 and beta-2 adrenergic receptor inhibitor, to lower elevated intraocular pressure.
Latanoprost is a prostaglandin F2-alpha analogue that reduces intraocular pressure by increasing uveoscleral outflow of aqueous humor.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Combigan
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Xalatan
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Combigan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Xalatan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Combigan
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Xalatan
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Combigan.
No savings programs available for Xalatan.
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CombiganView full Combigan profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.