| Ocular Hypertension
Cosopt PF vs Xalatan
Side-by-side clinical, coverage, and cost comparison for ocular hypertension.Deep comparison between: Cosopt Pf vs Xalatan with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXalatan has a higher rate of injection site reactions vs Cosopt Pf based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xalatan but not Cosopt Pf, including UnitedHealthcare
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Category
Cosopt Pf
Xalatan
At A Glance
Ophthalmic
Twice daily
Carbonic anhydrase inhibitor / beta-blocker
Ophthalmic
Once daily
Prostaglandin F2-alpha analogue
Indications
- Glaucoma, Open-Angle
- Ocular Hypertension
- Glaucoma, Open-Angle
- Ocular Hypertension
Dosing
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) twice daily; if other topical ophthalmic drugs are used, administer at least 5 minutes apart. Use the contents of each individual unit immediately after opening and discard any remaining solution.
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) once daily in the evening; do not exceed once daily dosing.
Contraindications
- Bronchial asthma or history of bronchial asthma, or severe chronic obstructive pulmonary disease
- Sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, or cardiogenic shock
- Hypersensitivity to any component of this product
- Known hypersensitivity to latanoprost, benzalkonium chloride, or any other ingredients in this product
Adverse Reactions
Most common (>=5%) Taste perversion (bitter, sour, or unusual taste), ocular burning and/or stinging (up to 30%), conjunctival hyperemia, blurred vision, superficial punctate keratitis, eye itching (5-15%)
Postmarketing Bradycardia, cardiac failure, cerebral vascular accident, chest pain, choroidal detachment following filtration surgery, depression, diarrhea, dry mouth, dyspnea, heart block, hypotension, iridocyclitis, myocardial infarction, nasal congestion, Stevens-Johnson syndrome, toxic epidermal necrolysis, paresthesia, photophobia, respiratory failure, skin rashes, urolithiasis, vomiting
Most common (5-15%) Foreign body sensation, punctate keratitis, stinging, conjunctival hyperemia, blurred vision, itching, burning, increased pigmentation of the iris
Serious Iris pigmentation changes, eyelid skin darkening, eyelash changes, intraocular inflammation (iritis/uveitis), macular edema including cystoid macular edema
Postmarketing Dizziness, headache, toxic epidermal necrolysis, keratitis, corneal edema and erosions, trichiasis, iris cyst, conjunctivitis, pseudopemphigoid of the ocular conjunctiva, asthma, dyspnea, nausea, vomiting, pruritis, herpes keratitis, angina, palpitations, chest pain
Pharmacology
COSOPT PF combines dorzolamide hydrochloride (carbonic anhydrase II inhibitor) and timolol maleate (non-selective beta1/beta2-adrenergic receptor blocker); both components independently reduce elevated intraocular pressure by decreasing aqueous humor secretion, with additive IOP-lowering effect when combined.
Latanoprost is a prostaglandin F2-alpha analogue that reduces intraocular pressure by increasing uveoscleral outflow of aqueous humor.
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Most Common Insurance
Anthem BCBS
Cosopt Pf
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Xalatan
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Cosopt Pf
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Xalatan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Cosopt Pf
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Xalatan
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Cosopt Pf.
No savings programs available for Xalatan.
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Cosopt PfView full Cosopt Pf profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.