| Ocular Hypertension
Travatan Z vs Alphagan P
Side-by-side clinical, coverage, and cost comparison for ocular hypertension.Deep comparison between: Travatan Z vs Alphagan P with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAlphagan P has a higher rate of injection site reactions vs Travatan Z based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Alphagan P but not Travatan Z, including UnitedHealthcare
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Category
Travatan Z
Alphagan P
At A Glance
Ophthalmic
Once daily (evening)
Prostaglandin analog
Ophthalmic
Three times daily
Alpha-2 adrenergic receptor agonist
Indications
- Glaucoma, Open-Angle
- Ocular Hypertension
- Glaucoma, Open-Angle
- Ocular Hypertension
Dosing
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) once daily in the evening; do not administer more than once daily. If used with other topical ophthalmic drugs, administer at least 5 minutes apart.
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) three times daily, approximately 8 hours apart; if used with other topical ophthalmic products, instill at least 5 minutes apart.
Contraindications
—
- Neonates and infants (pediatric patients younger than 2 years old)
- Previous hypersensitivity reaction to any component of ALPHAGAN P
Adverse Reactions
Most common (30% to 50%) Ocular hyperemia (conjunctival hyperemia)
Ocular (5% to 10%) Decreased visual acuity, eye discomfort, foreign body sensation, pain, pruritus
Postmarketing Arrhythmia, vomiting, epistaxis, tachycardia, insomnia, periorbital and lid changes including deepening of the eyelid sulcus
Most common (>=10%) Allergic conjunctivitis, conjunctival hyperemia, eye pruritus
Serious Potentiation of vascular insufficiency, severe cardiovascular disease
Postmarketing Bradycardia, depression, hypersensitivity, iritis, keratoconjunctivitis sicca, miosis, nausea, skin reactions, syncope, tachycardia
Pharmacology
Travoprost free acid is a selective FP prostanoid receptor agonist (prostaglandin analog) believed to reduce intraocular pressure by increasing uveoscleral outflow; the exact mechanism is unknown.
Brimonidine tartrate is a relatively selective alpha-2 adrenergic receptor agonist that lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow, with a peak ocular hypotensive effect at approximately 2 hours post-dosing.
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Most Common Insurance
Anthem BCBS
Travatan Z
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
Alphagan P
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Travatan Z
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Alphagan P
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Humana
Travatan Z
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (3/3) · Qty limit (2/3)
Alphagan P
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (3/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Travatan Z.
No savings programs available for Alphagan P.
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Travatan ZView full Travatan Z profile
Alphagan PView full Alphagan P profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.