| Ocular Hypertension
Travatan Z vs Combigan
Side-by-side clinical, coverage, and cost comparison for ocular hypertension.Deep comparison between: Travatan Z vs Combigan with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCombigan has a higher rate of injection site reactions vs Travatan Z based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Combigan but not Travatan Z, including UnitedHealthcare
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Category
Travatan Z
Combigan
At A Glance
Ophthalmic
Once daily (evening)
Prostaglandin analog
Topical (ophthalmic)
Twice daily
Alpha-2 agonist / beta-blocker
Indications
- Glaucoma, Open-Angle
- Ocular Hypertension
- Glaucoma
- Ocular Hypertension
Dosing
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) once daily in the evening; do not administer more than once daily. If used with other topical ophthalmic drugs, administer at least 5 minutes apart.
Glaucoma, Ocular Hypertension One drop in the affected eye(s) twice daily approximately 12 hours apart; if using multiple topical ophthalmic products, instill at least 5 minutes apart.
Contraindications
—
- Bronchial asthma, history of bronchial asthma, or severe chronic obstructive pulmonary disease
- Sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, or cardiogenic shock
- Neonates and infants (pediatric patients younger than 2 years old)
- Hypersensitivity to any component of this product
Adverse Reactions
Most common (30% to 50%) Ocular hyperemia (conjunctival hyperemia)
Ocular (5% to 10%) Decreased visual acuity, eye discomfort, foreign body sensation, pain, pruritus
Postmarketing Arrhythmia, vomiting, epistaxis, tachycardia, insomnia, periorbital and lid changes including deepening of the eyelid sulcus
Most common (5%-15%) allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, stinging
Serious hypersensitivity reactions, severe respiratory or cardiac reactions, cardiac failure, potentiation of vascular insufficiency, increased reactivity to allergens, potentiation of muscle weakness, masking of hypoglycemia, masking of thyrotoxicosis, ocular hypersensitivity
Postmarketing bradycardia, eyelid erythema, hypersensitivity, iritis, keratoconjunctivitis sicca, miosis, nausea, skin reactions, syncope, tachycardia
Pharmacology
Travoprost free acid is a selective FP prostanoid receptor agonist (prostaglandin analog) believed to reduce intraocular pressure by increasing uveoscleral outflow; the exact mechanism is unknown.
COMBIGAN combines brimonidine tartrate, a relatively selective alpha-2 adrenergic receptor agonist that reduces aqueous humor production and increases uveoscleral outflow, with timolol maleate, a non-selective beta-1 and beta-2 adrenergic receptor inhibitor, to lower elevated intraocular pressure.
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Most Common Insurance
Anthem BCBS
Travatan Z
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
Combigan
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Travatan Z
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Combigan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Humana
Travatan Z
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (3/3) · Qty limit (2/3)
Combigan
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Travatan Z.
No savings programs available for Combigan.
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Travatan ZView full Travatan Z profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.