| Osteoporosis
Evenity vs Tymlos
Side-by-side clinical, coverage, and cost comparison for osteoporosis.Deep comparison between: Evenity vs Tymlos with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTymlos has a higher rate of injection site reactions vs Evenity based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tymlos but not Evenity, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Evenity
Tymlos
At A Glance
SC injection
Every month
Sclerostin inhibitor
SC injection
Once daily
PTH1R agonist
Indications
- Osteoporosis
- Osteoporosis
Dosing
Osteoporosis 210 mg subcutaneously once every month for 12 doses, administered as two separate 105 mg/1.17 mL injections in the abdomen, thigh, or upper arm by a healthcare provider; supplement calcium and vitamin D during treatment.
Osteoporosis 80 mcg subcutaneously once daily into the periumbilical region of the abdomen; treatment duration not to exceed 2 years during a patient's lifetime.
Contraindications
- Hypocalcemia (correct pre-existing hypocalcemia prior to initiating therapy)
- History of systemic hypersensitivity to romosozumab-aqqg or any component of the product formulation, including angioedema, erythema multiforme, and urticaria
- History of systemic hypersensitivity to abaloparatide or any component of the product formulation
Adverse Reactions
Most common (>=5%) Arthralgia, headache
Serious Major adverse cardiac events (myocardial infarction, stroke, cardiovascular death), hypersensitivity reactions (angioedema), hypocalcemia, osteonecrosis of the jaw, atypical subtrochanteric and diaphyseal femoral fractures
Most common (>=2%) Hypercalciuria, dizziness, nausea, headache, palpitations, fatigue, abdominal pain upper, vertigo, injection site redness, injection site edema, injection site pain, tachycardia
Serious Orthostatic hypotension, hypercalcemia, hypercalciuria and urolithiasis
Postmarketing Abdominal distension, abdominal pain, constipation, diarrhea, vomiting, decreased appetite, asthenia, lethargy, malaise, hot flush, insomnia, hypersensitivity and anaphylactic reactions, dyspnea, pruritus, rash, generalized pain, blood pressure increased, muscle spasms, injection site bruising and hemorrhage
Pharmacology
Sclerostin inhibitor; humanized IgG2 monoclonal antibody that increases bone formation and, to a lesser extent, decreases bone resorption by inhibiting sclerostin, a regulatory factor in bone metabolism that suppresses osteoblastic activity.
Abaloparatide is a PTHrP(1-34) analog that acts as an agonist at the PTH1 receptor (PTH1R), activating the cAMP signaling pathway and stimulating osteoblastic activity to promote new bone formation on trabecular and cortical bone surfaces.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Evenity
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Tymlos
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (12/12) · Qty limit (12/12)
UnitedHealthcare
Evenity
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (1/8)
Tymlos
- Covered on 4 commercial plans
- PA (8/8) · Step Therapy (8/8) · Qty limit (3/8)
Humana
Evenity
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Tymlos
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAmgen Safety Net Foundation
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Neurofibromatosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
EvenityView full Evenity profile
TymlosView full Tymlos profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.