| Osteoporosis
Prolia vs Forteo
Side-by-side clinical, coverage, and cost comparison for osteoporosis.Deep comparison between: Prolia vs Forteo with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsForteo has a higher rate of injection site reactions vs Prolia based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Forteo but not Prolia, including UnitedHealthcare
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Category
Prolia
Forteo
At A Glance
SC injection
Every 6 months
RANKL inhibitor
SC injection
Once daily
PTH analog
Indications
- Osteoporosis, Postmenopausal
- Osteoporosis
- Osteoporosis steroid-induced
- Osteoporosis
- Primary osteoporosis
- Osteoporosis steroid-induced
Dosing
Osteoporosis, Postmenopausal, Osteoporosis, Osteoporosis steroid-induced 60 mg as a single subcutaneous injection once every 6 months in the upper arm, upper thigh, or abdomen; all patients should receive calcium 1000 mg daily and at least 400 IU vitamin D daily.
Osteoporosis, Primary osteoporosis, Osteoporosis steroid-induced 20 mcg subcutaneously once daily into the thigh or abdominal region; use for more than 2 years during a patient's lifetime only if the patient remains at or has returned to high risk for fracture.
Contraindications
- Pre-existing hypocalcemia
- Pregnancy
- Hypersensitivity to any component of Prolia (including anaphylaxis, facial swelling, and urticaria)
- Hypersensitivity to teriparatide or any of its excipients
Adverse Reactions
Most common (>=2%) Back pain, pain in extremity, musculoskeletal pain, hypercholesterolemia, cystitis
Serious Severe hypocalcemia, hypersensitivity reactions, osteonecrosis of the jaw, atypical subtrochanteric and diaphyseal femoral fractures, multiple vertebral fractures following discontinuation, serious infections, dermatologic adverse reactions
Postmarketing Anaphylaxis, rash, urticaria, facial swelling, erythema, severe symptomatic hypocalcemia, severe musculoskeletal pain, marked PTH elevation in severe renal impairment, multiple vertebral fractures following discontinuation, cutaneous lichenoid drug eruptions, alopecia, vasculitis, DRESS syndrome
Most common (>10%) Arthralgia, pain, nausea
Postmarketing Anaphylactic reactions, angioedema, urticaria, drug hypersensitivity, osteosarcoma, hyperuricemia, acute dyspnea, chest pain, muscle spasms of the leg or back, injection site reactions, oro-facial edema
Pharmacology
RANKL inhibitor; human IgG2 monoclonal antibody that binds RANKL, preventing RANKL/RANK interaction on osteoclasts and their precursors, thereby inhibiting osteoclast formation, function, and survival to decrease bone resorption and increase bone mass and strength in both cortical and trabecular bone.
Teriparatide is a recombinant human parathyroid hormone analog (PTH 1-34) that binds PTH cell-surface receptors and stimulates new bone formation by preferential stimulation of osteoblastic over osteoclastic activity on trabecular and cortical bone surfaces.
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Most Common Insurance
Anthem BCBS
Prolia
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (11/12) · Qty limit (11/12)
Forteo
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
UnitedHealthcare
Prolia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Forteo
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (0/8)
Humana
Prolia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Forteo
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Prolia.
Cost estimate not availableAssistance Fund: Neurofibromatosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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ProliaView full Prolia profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.