| Osteoporosis
Prolia vs Tymlos
Side-by-side clinical, coverage, and cost comparison for osteoporosis.Deep comparison between: Prolia vs Tymlos with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTymlos has a higher rate of injection site reactions vs Prolia based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tymlos but not Prolia, including UnitedHealthcare
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Category
Prolia
Tymlos
At A Glance
SC injection
Every 6 months
RANKL inhibitor
SC injection
Once daily
PTH1R agonist
Indications
- Osteoporosis, Postmenopausal
- Osteoporosis
- Osteoporosis steroid-induced
- Osteoporosis
Dosing
Osteoporosis, Postmenopausal, Osteoporosis, Osteoporosis steroid-induced 60 mg as a single subcutaneous injection once every 6 months in the upper arm, upper thigh, or abdomen; all patients should receive calcium 1000 mg daily and at least 400 IU vitamin D daily.
Osteoporosis 80 mcg subcutaneously once daily into the periumbilical region of the abdomen; treatment duration not to exceed 2 years during a patient's lifetime.
Contraindications
- Pre-existing hypocalcemia
- Pregnancy
- Hypersensitivity to any component of Prolia (including anaphylaxis, facial swelling, and urticaria)
- History of systemic hypersensitivity to abaloparatide or any component of the product formulation
Adverse Reactions
Most common (>=2%) Back pain, pain in extremity, musculoskeletal pain, hypercholesterolemia, cystitis
Serious Severe hypocalcemia, hypersensitivity reactions, osteonecrosis of the jaw, atypical subtrochanteric and diaphyseal femoral fractures, multiple vertebral fractures following discontinuation, serious infections, dermatologic adverse reactions
Postmarketing Anaphylaxis, rash, urticaria, facial swelling, erythema, severe symptomatic hypocalcemia, severe musculoskeletal pain, marked PTH elevation in severe renal impairment, multiple vertebral fractures following discontinuation, cutaneous lichenoid drug eruptions, alopecia, vasculitis, DRESS syndrome
Most common (>=2%) Hypercalciuria, dizziness, nausea, headache, palpitations, fatigue, abdominal pain upper, vertigo, injection site redness, injection site edema, injection site pain, tachycardia
Serious Orthostatic hypotension, hypercalcemia, hypercalciuria and urolithiasis
Postmarketing Abdominal distension, abdominal pain, constipation, diarrhea, vomiting, decreased appetite, asthenia, lethargy, malaise, hot flush, insomnia, hypersensitivity and anaphylactic reactions, dyspnea, pruritus, rash, generalized pain, blood pressure increased, muscle spasms, injection site bruising and hemorrhage
Pharmacology
RANKL inhibitor; human IgG2 monoclonal antibody that binds RANKL, preventing RANKL/RANK interaction on osteoclasts and their precursors, thereby inhibiting osteoclast formation, function, and survival to decrease bone resorption and increase bone mass and strength in both cortical and trabecular bone.
Abaloparatide is a PTHrP(1-34) analog that acts as an agonist at the PTH1 receptor (PTH1R), activating the cAMP signaling pathway and stimulating osteoblastic activity to promote new bone formation on trabecular and cortical bone surfaces.
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Most Common Insurance
Anthem BCBS
Prolia
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (11/12) · Qty limit (11/12)
Tymlos
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (12/12) · Qty limit (12/12)
UnitedHealthcare
Prolia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Tymlos
- Covered on 4 commercial plans
- PA (8/8) · Step Therapy (8/8) · Qty limit (3/8)
Humana
Prolia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Tymlos
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Prolia.
Cost estimate not availableAssistance Fund: Neurofibromatosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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ProliaView full Prolia profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.