| Pain in female genitalia on intercourse
Osphena vs Intrarosa
Side-by-side clinical, coverage, and cost comparison for pain in female genitalia on intercourse.Deep comparison between: Osphena vs Intrarosa with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsIntrarosa has a higher rate of injection site reactions vs Osphena based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Intrarosa but not Osphena, including UnitedHealthcare
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Category
Osphena
Intrarosa
At A Glance
Oral
Daily
Estrogen receptor agonist/antagonist
Vaginal insert
Once daily
Endogenous steroid
Indications
- Pain in female genitalia on intercourse
- Postmenopausal atrophic vaginitis
- Pain in female genitalia on intercourse
Dosing
Pain in female genitalia on intercourse, Postmenopausal atrophic vaginitis One 60 mg tablet taken orally with food once daily.
Pain in female genitalia on intercourse One vaginal insert once daily at bedtime using the provided applicator.
Contraindications
- Undiagnosed abnormal genital bleeding
- Estrogen-dependent neoplasia
- Active DVT, PE, or history of these conditions
- Active arterial thromboembolic disease (e.g., stroke, MI) or history of these conditions
- Hypersensitivity (e.g., angioedema, urticaria, rash, pruritus) to ospemifene or any ingredient
- Pregnancy or potential pregnancy
- Undiagnosed, persistent, or recurring abnormal genital bleeding
Adverse Reactions
Most common (>=1%) Hot flush, vaginal discharge, muscle spasms, hyperhidrosis
Serious Thromboembolic stroke, hemorrhagic stroke, DVT, malignant neoplasms
Postmarketing Endometrial hyperplasia, endometrial cancer, hypersensitivity, angioedema, headache, deep vein thrombosis, pulmonary embolism, rash, pruritus, urticaria
Most common (>=2%) Vaginal discharge, abnormal Pap smear
Pharmacology
Ospemifene is an estrogen receptor agonist/antagonist with tissue-selective effects, activating estrogenic pathways in some tissues (agonism) and blocking them in others (antagonism).
Prasterone is an inactive endogenous steroid that is converted into active androgens and/or estrogens via human steroidogenic enzymes; its mechanism of action in postmenopausal women with vulvar and vaginal atrophy is not fully established.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Osphena
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Intrarosa
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (5/12) · Qty limit (9/12)
UnitedHealthcare
Osphena
- Covered on 4 commercial plans
- PA (8/8) · Step Therapy (0/8) · Qty limit (8/8)
Intrarosa
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (5/8)
Humana
Osphena
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Intrarosa
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Osphena.
No savings programs available for Intrarosa.
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OsphenaView full Osphena profile
IntrarosaView full Intrarosa profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.