| Parkinson Disease
Ongentys vs Nourianz
Side-by-side clinical, coverage, and cost comparison for parkinson disease.Deep comparison between: Ongentys vs Nourianz with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNourianz has a higher rate of injection site reactions vs Ongentys based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nourianz but not Ongentys, including UnitedHealthcare
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Category
Ongentys
Nourianz
At A Glance
Oral
Daily
COMT inhibitor
Oral
Daily
Adenosine A2A receptor antagonist
Indications
- Parkinson Disease
- Parkinson Disease
Dosing
Parkinson Disease 50 mg orally once daily at bedtime; avoid food 1 hour before and at least 1 hour after dose; reduce to 25 mg in moderate hepatic impairment (Child-Pugh B); avoid use in severe hepatic impairment (Child-Pugh C).
Parkinson Disease 20 mg orally once daily; may increase to 40 mg once daily based on individual need and tolerability; may be taken with or without food; max 20 mg once daily with strong CYP3A4 inhibitors or moderate hepatic impairment; 40 mg once daily in tobacco smokers (>=20 cigarettes/day); avoid with strong CYP3A4 inducers or in severe hepatic impairment.
Contraindications
- Concomitant use of non-selective monoamine oxidase (MAO) inhibitors
- Pheochromocytoma, paraganglioma, or other catecholamine secreting neoplasms
—
Adverse Reactions
Most common (>=4%) Dyskinesia, constipation, blood creatine kinase increased, hypotension/syncope, weight decreased
Serious Cardiovascular effects with COMT-metabolized drugs, falling asleep during activities of daily living, hypotension/syncope, dyskinesia, hallucinations and psychosis, impulse control/compulsive disorders, withdrawal-emergent hyperpyrexia and confusion
Postmarketing Fall
Most common (>=5%) Dyskinesia, dizziness, constipation, nausea, hallucination, insomnia
Serious Dyskinesia, hallucinations/psychotic behavior, impulse control/compulsive behaviors
Postmarketing Increased libido
Pharmacology
Opicapone is a peripheral, selective and reversible inhibitor of catechol-O-methyltransferase (COMT) that reduces levodopa breakdown to 3-OMD, thereby increasing levodopa exposure in Parkinson's disease patients treated with levodopa/carbidopa.
Adenosine A2A receptor antagonist; istradefylline is a xanthine derivative demonstrated in vitro and in animal studies to block adenosine A2A receptors, though the precise mechanism of therapeutic action in Parkinson's disease is unknown.
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Most Common Insurance
Anthem BCBS
Ongentys
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
Nourianz
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Ongentys
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (2/8) · Qty limit (1/8)
Nourianz
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (0/8)
Humana
Ongentys
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Nourianz
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Ongentys.
$20/fillfill
Nourianz Copay Assistance ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.