| Prostate carcinoma

Zoladex vs Axumin

Side-by-side clinical, coverage, and cost comparison for prostate carcinoma.
Deep comparison between: Zoladex vs Axumin with Prescriber.AI
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Safety signalsAxumin has a higher rate of injection site reactions vs Zoladex based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Axumin but not Zoladex, including UnitedHealthcare
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Zoladex
Axumin
At A Glance
SC injection
Every 28 days
GnRH agonist
IV injection
Single dose
Amino acid PET radiotracer
Indications
  • Prostate carcinoma
  • Endometriosis
  • Abnormal uterine bleeding
  • Breast Carcinoma
  • Prostate carcinoma
Dosing
Prostate carcinoma (Stage B2-C) 3.6 mg SC every 28 days starting 8 weeks before radiotherapy, in combination with flutamide, continued during radiation therapy; alternatively, a 10.8 mg depot may follow the initial 3.6 mg depot.
Prostate carcinoma (advanced) 3.6 mg SC every 28 days; intended for long-term administration.
Endometriosis 3.6 mg SC every 28 days for 6 months.
Abnormal uterine bleeding One or two 3.6 mg SC depots given 4 weeks apart; surgery performed at 4 weeks after one depot, or within 2-4 weeks after the second depot.
Breast Carcinoma 3.6 mg SC every 28 days; intended for long-term administration.
Prostate carcinoma 370 MBq (10 mCi) intravenous bolus injection; begin PET imaging 3-5 minutes after administration; scan from mid-thigh to base of skull over approximately 20-30 minutes.
Contraindications
  • Known hypersensitivity to GnRH, GnRH agonist analogues, or any component of ZOLADEX
  • Pregnancy (except when used for palliative treatment of advanced breast cancer)
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Adverse Reactions
Most common (>10%) in men Hot flashes, sexual dysfunction, decreased erections, lower urinary tract symptoms
Most common (>20%) in women Hot flushes, headache, sweating, acne, emotional lability, depression, decreased libido, vaginitis, breast atrophy, seborrhea, peripheral edema
Serious Tumor flare, ureteral obstruction, spinal cord compression, pituitary apoplexy
Postmarketing Osteoporosis, bone fracture, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, transient ischemic attack, ovarian cyst, pituitary adenoma, SJS/TEN, DRESS, AGEP, erythema multiforme, psychotic disorders, suicidal ideation, convulsions
Most common (<=1%) injection site pain, injection site erythema, dysgeusia
Pharmacology
ZOLADEX is a synthetic decapeptide analogue of GnRH that inhibits pituitary gonadotropin secretion; chronic administration suppresses serum testosterone in males to castrate levels and reduces serum estradiol in females to postmenopausal levels, leading to regression of hormone-sensitive tumors and accessory sex organ regression.
Fluciclovine F 18 is a synthetic amino acid analog transported across mammalian cell membranes by amino acid transporters (LAT-1 and ASCT2) that are upregulated in prostate cancer cells, resulting in greater uptake in prostate cancer cells compared with surrounding normal tissues.
View Full FDA Information
View full FDA information
View full FDA information
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Zoladex
  • Covered on 5 commercial plans
  • PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
View full coverage details ›
No coverage data available for Axumin.
UnitedHealthcare
Zoladex
  • Covered on 4 commercial plans
  • PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
View full coverage details ›
No coverage data available for Axumin.
Humana
Zoladex
  • Covered on 0 commercial plans
  • PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
View full coverage details ›
No coverage data available for Axumin.
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zoladex.
No savings programs available for Axumin.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.